Human CETN2 Recombinant Protein (RPPB3152)

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SKU:
RPPB3152
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CETN2
Synonyms:
Centrin-2
Synonyms:
Caltractin isoform 1
Synonyms:
CETN2
Synonyms:
CALT
Source:
Escherichia Coli
Uniprot:
P41208
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Description

Product Name:Human CETN2 Recombinant Protein
Product Code:RPPB3152
Size:10µg
Species:Human
Target:CETN2
Synonyms:Centrin-2, Caltractin isoform 1, CETN2, CALT, CEN2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CETN2 solution (0.5 mg/ml) 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV KELKVAMRAL GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVSEQ EFLRIMKKTS LY

Caltractin (CETN2) is a member of a family of calcium-binding proteins and is a structural component of the centrosome. CETN2 has a role in nucleotide excision repair via association with xeroderma pigmentosum group C protein, suggesting possible coupling of cell division and nucleotide excision repair.

CETN2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular mass of 21.9kDa. The CETN2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CETN2: a calcium-binding proteins and is a structural component of the centrosome. Contains 4 EF-hand calcium-binding domains. Highly conserved from algae to humans. Its association with the centrosome suggests that it plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.
UniProt Protein Details:

Protein type:DNA repair, damage; Calcium-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: centriole; centrosome; intracellular; cytosol; photoreceptor connecting cilium

Molecular Function:protein binding; microtubule binding; G-protein beta/gamma-subunit binding; calcium ion binding; heterotrimeric G-protein binding

Biological Process: mitosis; cell division; nucleotide-excision repair; organelle organization and biogenesis; centriole replication; spermatogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cytokinesis

NCBI Summary:Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]
UniProt Code:P41208
NCBI GenInfo Identifier:729052
NCBI Gene ID:1069
NCBI Accession:P41208.1
UniProt Secondary Accession:P41208,Q53XW1, B2R4T4,
UniProt Related Accession:P41208
Molecular Weight:172
NCBI Full Name:Centrin-2
NCBI Synonym Full Names:centrin, EF-hand protein, 2
NCBI Official Symbol:CETN2  
NCBI Official Synonym Symbols:CALT; CEN2  
NCBI Protein Information:centrin-2; caltractin (20kD calcium-binding protein)
UniProt Protein Name:Centrin-2
UniProt Synonym Protein Names:Caltractin isoform 1
Protein Family:Centrin
UniProt Gene Name:CETN2  
UniProt Entry Name:CETN2_HUMAN
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