Human CENPP Recombinant Protein (RPPB3148)

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SKU:
RPPB3148
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CENPP
Synonyms:
Centromere protein P
Synonyms:
CENP-P
Synonyms:
CENPP
Source:
Escherichia Coli
Uniprot:
Q6IPU0
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Description

Product Name:Human CENPP Recombinant Protein
Product Code:RPPB3148
Size:20µg
Species:Human
Target:CENPP
Synonyms:Centromere protein P, CENP-P, CENPP.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:CENPP protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW KSSKDLKNQL GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK VLQRHRLSGN CHMVTFQLEF QILEIQNKER LSSAVTDLNI IMEPTECSEL SEFVSRAEER KDLFMFFRSL HFFVEWFEYR KRTFKHLKEK YPDAVYLSEG PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT KVPQRALELD KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN

Centromere protein P (CENPP) is component of the CENPA-CAD (nucleosome distal) complex, which is a complex recruited to centromeres and involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. CENPP protein is involved in incorporation of newly synthesized CENPA into centromeres by way of its interaction with the CENPA-NAC complex.

CENPP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-288 a.a) and having a molecular mass of 35.3kDa.CENPP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CENPP: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.Chromosomal Location of Human Ortholog: 9q22.31Cellular Component: nucleoplasm; cytosol; chromosome, pericentric regionBiological Process: nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle
UniProt Protein Details:
NCBI Summary:CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
UniProt Code:Q6IPU0
NCBI GenInfo Identifier:47939542
NCBI Gene ID:401541
NCBI Accession:AAH71726.1
UniProt Secondary Accession:Q6IPU0,Q5T9F8, Q5T9F9, B3KRA5, B3KS17
UniProt Related Accession:Q6IPU0
Molecular Weight:12,707 Da
NCBI Full Name:Centromere protein P
NCBI Synonym Full Names:centromere protein P
NCBI Official Symbol:CENPP  
NCBI Official Synonym Symbols:CENP-P  
NCBI Protein Information:centromere protein P
UniProt Protein Name:Centromere protein P
UniProt Synonym Protein Names:
Protein Family:Centromere protein
UniProt Gene Name:CENPP  
UniProt Entry Name:CENPP_HUMAN
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