Human CDC26 Recombinant Protein (RPPB3117)

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SKU:
RPPB3117
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CDC26
Synonyms:
Anaphase-promoting complex subunit CDC26
Synonyms:
Anaphase-promoting complex subunit 12
Synonyms:
APC12
Synonyms:
Cell division cycle protein 26 homolog
Source:
Escherichia Coli
Uniprot:
Q8NHZ8
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Description

Product Name:Human CDC26 Recombinant Protein
Product Code:RPPB3117
Size:20µg
Species:Human
Target:CDC26
Synonyms:Anaphase-promoting complex subunit CDC26, Anaphase-promoting complex subunit 12, APC12, Cell division cycle protein 26 homolog, CDC26, ANAPC12, C9orf17.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CDC26 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL SSDPKSREQM INDRIGYKPQ PKPNNRSSQF GSLEF

CDC26 is a member of the CDC26 family which arranges progression via mitosis by enhancing cell-cycle regulators with ubiquitin chains. CDC26 is a component of the anaphase promoting complex/cyclosome (APC/C), which is a cell cycle-regulated E3 ubiquitin ligase which directs progression through mitosis and the G1 phase of the cell cycle. The APC/C complex operates by mediating ubiquitination and subsequent degradation of target proteins.

CDC26 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 105 amino acids (1-85 a.a) and having a molecular mass of 11.9kDa.CDC26 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CDC26: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. Belongs to the CDC26 family.Chromosomal Location of Human Ortholog: 9q32Cellular Component: nucleoplasm; anaphase-promoting complex; cytosolMolecular Function: protein bindingBiological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NHZ8
NCBI GenInfo Identifier:21281671
NCBI Gene ID:246184
NCBI Accession:NP_644815.1
UniProt Secondary Accession:Q8NHZ8
UniProt Related Accession:Q8NHZ8
Molecular Weight:9,777 Da
NCBI Full Name:anaphase-promoting complex subunit CDC26
NCBI Synonym Full Names:cell division cycle 26
NCBI Official Symbol:CDC26  
NCBI Official Synonym Symbols:APC12; ANAPC12; C9orf17  
NCBI Protein Information:anaphase-promoting complex subunit CDC26; cell division cycle 26 homolog; anaphase-promoting complex subunit 12; cell division cycle protein 26 homolog; CDC26 subunit of anaphase promoting complex
UniProt Protein Name:Anaphase-promoting complex subunit CDC26
UniProt Synonym Protein Names:Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homolog
Protein Family:Anaphase-promoting complex
UniProt Gene Name:CDC26  
UniProt Entry Name:CDC26_HUMAN
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