Human CD57 Recombinant Protein (RPPB5877)

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SKU:
RPPB5877
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CD57
Synonyms:
B3GAT1
Synonyms:
CD57
Synonyms:
GLCATP
Synonyms:
GLCUATP
Source:
Sf9 Insect cells
Uniprot:
Q9P2W7
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Description

Product Name:Human CD57 Recombinant Protein
Product Code:RPPB5877
Size:10µg
Species:Human
Target:CD57
Synonyms:B3GAT1, CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, Beta-1,3-glucuronyltransferase 1, Glucuronosyltransferase P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, GlcUAT-P.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:The  CD57 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 10% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPTLAPLLA VHKDEGSDPR RETPPGADPR EYCTSDRDIV EVVRTEYVYT RPPPWSDTLPTIHVVTPTYS RPVQKAELTR MANTLLHVPN LHWLVVEDAP RRTPLTARLL RDTGLNYTHLHVETPRNYKL RGDARDPRIP RGTMQRNLAL RWLRETFPRN SSQPGVVYFA DDDNTYSLELFEEMRSTRRV SVWPVAFVGG LRYEAPRVNG AGKVVGWKTV FDPHRPFAID MAGFAVNLRLILQRSQAYFK LRGVKGGYQE SSLLRELVTL NDLEPKAANC TKILVWHTRT EKPVLVNEGKKGFTDPSVEI LEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVVDVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVSNKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESNGQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKHHHHHH

CD57 also called B3GAT1is part of the glucuronyltransferase gene family. CD57 exhibits strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. CD57 takes part in the glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1.

CD57 Human Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 549 amino acids (28-334aa) and having a molecular mass of 62.3kDa.CD57 is fused to a 242 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:B3GAT1: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Belongs to the glycosyltransferase 43 family.
UniProt Protein Details:

Protein type:EC 2.4.1.135; Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: Golgi membrane

Molecular Function:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

Biological Process: carbohydrate metabolic process; chondroitin sulfate metabolic process; chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan metabolic process

NCBI Summary:The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q9P2W7
NCBI GenInfo Identifier:205830910
NCBI Gene ID:27087
NCBI Accession:Q9P2W7.2
UniProt Secondary Accession:Q9P2W7,Q96FS7,
UniProt Related Accession:Q9P2W7
Molecular Weight:38,256 Da
NCBI Full Name:Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
NCBI Synonym Full Names:beta-1,3-glucuronyltransferase 1
NCBI Official Symbol:B3GAT1  
NCBI Official Synonym Symbols:NK1; CD57; HNK1; LEU7; NK-1; GLCATP; GLCUATP  
NCBI Protein Information:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
UniProt Protein Name:Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
UniProt Synonym Protein Names:Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase P; GlcAT-P; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; GlcUAT-P
Protein Family:Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
UniProt Gene Name:B3GAT1  
UniProt Entry Name:B3GA1_HUMAN
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