PerCP/Cyanine5.5 Anti-Human CD49d Antibody [9F10] (AGEL1743)

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SKU:
AGEL1743
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PerCP/Cyanine5.5 Anti-Human CD49d Antibody [9F10]

The Monoclonal antibody PERCP-CY5.5 Conjugated 9F10 (AGE1743) is a cutting-edge research tool designed for studying human CD49d, a key cell surface molecule involved in cell adhesion and migration processes. This highly specific antibody, conjugated with PERCP-CY5.5 for enhanced detection capabilities, is ideal for flow cytometry applications targeting CD49d-expressing cells in various research contexts.CD49d, also known as integrin alpha 4, is a vital component of integrin heterodimers, playing a crucial role in mediating cell-to-cell and cell-to-extracellular matrix interactions.

Its involvement in cell adhesion and migration processes makes it a significant target for investigations in immunology, oncology, and regenerative medicine. The Monoclonal antibody PERCP-CY5.5 Conjugated 9F10 provides researchers with a powerful tool to detect and analyze CD49d expression levels in different cell populations, facilitating a deeper understanding of its functions and potential therapeutic implications.

Product Title:PerCP/Cyanine5.5 Anti-Human CD49d Antibody [9F10]
SKU:AGEL1743
Size:20 Tests, 100 Tests, 200 Tests
Clone No:9F10
Synonyms:Integrin alpha-4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d;ITGA4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13612
Gene ID:3676
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

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