PE/Cyanine5.5 Anti-Human CD49d Antibody [9F10] (AGEL1742)

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SKU:
AGEL1742
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Human CD49d Antibody [9F10]

The Human CD49d Monoclonal Antibody (PE/Cyanine5.5 Conjugated, 9F10) is a cutting-edge tool designed for researchers studying CD49d, a crucial cell surface molecule involved in cell adhesion and migration processes. This monoclonal antibody, conjugated with PE/Cyanine5.5, offers high specificity and sensitivity for detecting CD49d in human samples, making it an essential component for flow cytometry and immunofluorescence applications.CD49d, also known as integrin alpha-4, is a key player in cell interactions within the immune system, particularly in leukocyte trafficking and homing to inflamed tissues. Its role in inflammation and immune response modulation positions it as a significant target for investigations in immunology, autoimmune diseases, and inflammatory conditions.

By enabling the precise detection of CD49d expression, this antibody facilitates detailed analysis of cell populations and their behavior, aiding in the understanding of immune system dynamics and disease mechanisms.Researchers utilizing the Human CD49d Monoclonal Antibody (PE/Cyanine5.5 Conjugated, 9F10) can delve deeper into the intricate functions of CD49d and its implications in various physiological and pathological processes. With its reliable performance and proven compatibility with advanced imaging techniques, this antibody empowers scientists to explore new avenues in immunological research and potentially uncover innovative therapeutic strategies targeting CD49d-related pathways.

Product Title:PE/Cyanine5.5 Anti-Human CD49d Antibody [9F10]
SKU:AGEL1742
Size:20 Tests, 100 Tests, 200 Tests
Clone No:9F10
Synonyms:Integrin alpha-4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d;ITGA4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13612
Gene ID:3676
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

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