PE/Cyanine5 Anti-Human CD47 Antibody [CC2C6D4] (AGEL0995)

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SKU:
AGEL0995
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5 Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody (PE/Cyanine5 Conjugated) is a specialized tool for research involving CD47, a cell surface protein known for its role in immune evasion and cancer progression. This monoclonal antibody, designated as CC2C6D4-AGEL0995, is specifically designed to target human CD47 and is conjugated with PE/Cyanine5 for enhanced detection and analysis.CD47, commonly referred to as the "don't eat me" signal, is a key player in immune checkpoint pathways, allowing cancer cells to evade destruction by the immune system. Research indicates that CD47 overexpression is associated with poor prognosis in various malignancies, making it a promising target for cancer immunotherapy.

The CD47 Monoclonal Antibody facilitates the study of CD47 expression and function in different cell types, providing valuable insights for cancer biology and immunotherapy research.By enabling precise detection and measurement of CD47 levels, this antibody assists in understanding the mechanisms of immune evasion and developing targeted therapies to enhance anti-tumor immune responses. Its application extends to studies exploring the interaction between CD47 and immune cells, helping researchers unravel the complexities of immune checkpoint modulation in cancer and other diseases.

Product Title:PE/Cyanine5 Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0995
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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