PE Anti-Human CD47 Antibody [CC2C6D4] (AGEL0252)

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SKU:
AGEL0252
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
CC2C6D4
Conjugation:
PE
Applications:
FC
Frequently bought together:

Description

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PE Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody PE Conjugated (clone CC2C6D4) is a cutting-edge research tool offered by Assay Genie. This antibody is specifically designed to target CD47, a cell surface protein involved in multiple physiological processes, including immune evasion and regulation. The unique PE conjugation enhances the antibody's detection capabilities, making it suitable for flow cytometry and fluorescence microscopy applications.CD47, known as the "don't eat me" signal, plays a crucial role in modulating immune responses by interacting with signal-regulatory protein alpha (SIRPα) on phagocytic cells. Research has shown that dysregulation of the CD47-SIRPα interaction is implicated in various diseases, such as cancer and autoimmune disorders.

By utilizing the Human CD47 Monoclonal Antibody PE Conjugated, researchers can explore the expression and function of CD47 in different cell types, shedding light on its role in disease pathology and immune system evasion mechanisms.This advanced antibody product from Assay Genie provides a valuable tool for researchers in immunology, oncology, and drug development. With its high specificity and sensitivity, the Human CD47 Monoclonal Antibody PE Conjugated (CC2C6D4) is a powerhouse for elucidating the intricate functions of CD47 and its therapeutic implications.

Product Title:PE Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0252
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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