FITC Anti-Human CD274/PD-L1 Antibody [29E.2A3] (AGEL1648)

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SKU:
AGEL1648
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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FITC Anti-Human CD274/PD-L1 Antibody [29E.2A3]

The Human CD274 (PD-L1) Monoclonal Antibody (FITC Conjugated) 29E.2A3 (AGEL1648) is specifically designed for research involving the CD274 (PD-L1) protein, a key immune checkpoint molecule that plays a significant role in regulating immune responses. This monoclonal antibody, conjugated with FITC for fluorescence detection, is highly reactive with human samples and has been thoroughly validated for use in various applications, including flow cytometry and immunofluorescence.CD274, also known as Programmed Death-Ligand 1 (PD-L1), is a crucial immune checkpoint molecule that interacts with its receptor PD-1 to regulate T cell function and maintain immune tolerance. Aberrant expression of PD-L1 has been implicated in immune evasion by cancer cells and other pathological conditions, making it a promising target for immunotherapy research and biomarker studies.

By specifically binding to CD274 (PD-L1), the 29E.2A3 monoclonal antibody enables precise detection and analysis of this important immune regulator in different cell types and tissues. Its applications in immunology, oncology, and immunotherapy research make it an indispensable tool for understanding the role of PD-L1 in immune evasion mechanisms and developing novel therapeutic strategies targeting the PD-1/PD-L1 pathway.Overall, the Human CD274 (PD-L1) Monoclonal Antibody (FITC Conjugated) 29E.2A3 (AGEL1648) offers researchers a reliable and sensitive tool to advance their studies in immunology, cancer biology, and immune checkpoint blockade, ultimately contributing to the development of innovative treatments for various diseases.

Product Title:FITC Anti-Human CD274/PD-L1 Antibody [29E.2A3]
SKU:AGEL1648
Size:20 Tests, 100 Tests, 200 Tests
Clone No:29E.2A3
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:FITC Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q9NZQ7
Gene ID:29126
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

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