The Human CD27 Monoclonal Antibody (PE-Cyanine5.5 Conjugated) is a cutting-edge tool for researchers working in the field of immunology and cell biology. This antibody, designated as O323-AG EL1712, is meticulously developed for precise targeting of CD27, a protein found on the surface of human immune cells.CD27, also known as Tumor Necrosis Factor Receptor Superfamily Member 7 (TNFRSF7), is a crucial factor in regulating immune responses and promoting the activation and differentiation of T cells. The monoclonal antibody featured in this product is specifically engineered to recognize and bind to CD27 with high affinity, enabling researchers to accurately analyze and study the function of this important immune receptor.The PE-Cyanine5.5 conjugation enhances the fluorescent properties of this antibody, making it an excellent choice for flow cytometry and immunofluorescence applications.
Its reliable performance and specificity for CD27 make it an indispensable tool for investigating immune cell subsets, immune activation processes, and immune cell signaling pathways.Overall, the Human CD27 Monoclonal Antibody (PE-Cyanine5.5 Conjugated) is a valuable resource for scientists seeking to deepen their understanding of immune responses, T cell activation, and immune regulation in the context of various diseases and conditions. By utilizing this antibody, researchers can gain valuable insights into the role of CD27 in immune function and its potential implications for therapeutic interventions.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P26842
Gene ID:
939
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD27 is a 50-55 kD type I membrane protein also known as S152 and T14. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells, and NK cells. CD27 binds to CD70 and plays an important role in costimulation of T cell activation, and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-κB and SAPK/JNK activation.