APC Anti-Human CD196/CCR6 Antibody [G034E3] (AGEL1801)

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SKU:
AGEL1801
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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APC Anti-Human CD196/CCR6 Antibody [G034E3]

The Human CD196 (CCR6) Monoclonal Antibody (APC conjugated) is a valuable tool for researchers interested in studying the CCR6 cell surface molecule, known for its involvement in immune cell migration and inflammation. This monoclonal antibody, specifically designed for use in flow cytometry applications, is raised in mice and exhibits high reactivity with human samples.CCR6, a chemokine receptor, plays a crucial role in directing immune cell trafficking to sites of inflammation and infection. Its expression is associated with specific subsets of immune cells, such as Th17 cells, Treg cells, and dendritic cells.

By targeting CCR6 with this monoclonal antibody, researchers can analyze and characterize these immune cell populations in different biological contexts.The use of the Human CD196 (CCR6) Monoclonal Antibody (APC conjugated) opens up opportunities to explore the role of CCR6 in various immune responses, including those related to autoimmune diseases, inflammatory conditions, and infectious processes. By understanding the function of CCR6, researchers can gain insights into potential therapeutic targets for modulating immune cell behavior and inflammation.

Product Title:APC Anti-Human CD196/CCR6 Antibody [G034E3]
SKU:AGEL1801
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G034E3
Synonyms:CKRL3; CMKBR6; GPR29; STRL22;GPRCY4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:APC Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P51684
Gene ID:1235
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

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