The Human CD147 Monoclonal Antibody (Biotin Conjugated) HIM6 (AGL0238) available at www.assaygenie.com is a precise tool designed for research applications involving CD147, a cell surface glycoprotein known to play key roles in various physiological and pathological processes. This monoclonal antibody, created using advanced technology, specifically targets the human CD147 protein, enabling its detection and analysis in a variety of cell types.CD147, also referred to as Basigin or EMMPRIN, is recognized for its involvement in processes such as cell adhesion, migration, and signal transduction, making it a significant target for studies in cell biology, immunology, and cancer research.
The antibody's biotin conjugation allows for easy and efficient detection through techniques like immunofluorescence, flow cytometry, and immunohistochemistry.Researchers interested in unraveling the complex functions of CD147 in health and disease, especially related to cancer metastasis, inflammatory responses, and cellular interactions, will find this monoclonal antibody to be a valuable asset in their experimental endeavors. Its specificity and reliability make it an essential tool for gaining insights into the molecular mechanisms underlying CD147-related processes, ultimately contributing to advancements in biomedical research and potential therapeutic interventions.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:
P35613
Gene ID:
682
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD147, also known as neurothelin or basigin, is a member of the Ig superfamily. It is a 55-65 kD type I transmembrane glycoprotein which is primarily expressed on leukocytes, erythrocytes, platelets, and endothelial cells. CD147 is reported to have a function during embryonal brain development and/or play a role in integrin-mediated adhesion in brain endothelia.