Human CCS Recombinant Protein (RPPB3001)

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SKU:
RPPB3001
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
CCS
Synonyms:
Superoxide dismutase copper chaperone
Synonyms:
Copper chaperone for superoxide dismutase
Source:
Escherichia Coli
Uniprot:
O14618
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Description

Product Name:Human CCS Recombinant Protein
Product Code:RPPB3001
Size:25µg
Species:Human
Target:CCS
Synonyms:Superoxide dismutase copper chaperone, Copper chaperone for superoxide dismutase.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The CCS protein solution (1mg/1ml) contains 20 mM Tris-HCl buffer (pH8.0), 1mM DTT, 0.2M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL

CCS is vital for the integration of copper into SOD-1, and as a result is needed for its enzymatic activity. CCS inhibits copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the required copper cofactor. CCS escorts copper just to SOD-1 and is unable to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. Although many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system.

CCS Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 294amino acids (1-274a.a.) and having a molecular wieght of 31.2kDa. The CCS is fused to a 20a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CCS: Delivers copper to copper zinc superoxide dismutase (SOD1).
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:copper ion transmembrane transporter activity; protein binding; copper ion binding; zinc ion binding; superoxide dismutase activity; protein disulfide oxidoreductase activity

Biological Process: response to reactive oxygen species; removal of superoxide radicals; superoxide metabolic process; intracellular copper ion transport; positive regulation of oxidoreductase activity

NCBI Summary:Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]
UniProt Code:O14618
NCBI GenInfo Identifier:20137612
NCBI Gene ID:9973
NCBI Accession:O14618.1
UniProt Secondary Accession:O14618,Q2M366, Q8NEV0,
UniProt Related Accession:O14618
Molecular Weight:274
NCBI Full Name:Copper chaperone for superoxide dismutase
NCBI Synonym Full Names:copper chaperone for superoxide dismutase
NCBI Official Symbol:CCS  
NCBI Protein Information:copper chaperone for superoxide dismutase; superoxide dismutase copper chaperone
UniProt Protein Name:Copper chaperone for superoxide dismutase
UniProt Synonym Protein Names:Superoxide dismutase copper chaperone
Protein Family:Capsanthin/capsorubin synthase
UniProt Gene Name:CCS  
UniProt Entry Name:CCS_HUMAN
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