Human CARD17 Recombinant Protein (RPPB2983)

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SKU:
RPPB2983
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CARD17
Synonyms:
CARD17
Synonyms:
Caspase Recruitment Domain Family
Synonyms:
Member 17
Synonyms:
Caspase recruitment domain-containing protein 17
Source:
Escherichia Coli
Uniprot:
Q5XLA6
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Description

Product Name:Human CARD17 Recombinant Protein
Product Code:RPPB2983
Size:20µg
Species:Human
Target:CARD17
Synonyms:CARD17, Caspase Recruitment Domain Family, Member 17, Caspase recruitment domain-containing protein 17, INCA, Caspase-1 inhibitor INCA, Inhibitory caspase recruitment domain protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CARD17 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMADKVLK EKRKQFIRSV GEGTINGLLG ELLETRVLSQ EEIEIVKCEN ATVMDKARAL LDSVIRKGAP ACQICITYIC EEDSHLAGTL GLSAGPTSGN HLTTQDSQIV LPS

Caspase Recruitment Domain Family, Member 17 (CARD17) is a regulator of procaspase-1/CASP1 activation involved in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release throughout inflammation. CARD17 inhibits the release of IL1B in reaction to LPS in monocytes. Though, unlike CASP1, CARD17 do not induce NF-kappa-B activation.

CARD17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-110) and having a molecular mass of 14.3 kDa.CARD17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q5XLA6
NCBI GenInfo Identifier:55925612
NCBI Gene ID:440068
NCBI Accession:NP_001007233.1
UniProt Secondary Accession:Q5XLA6
UniProt Related Accession:Q5XLA6
Molecular Weight:11,868 Da
NCBI Full Name:caspase recruitment domain-containing protein 17
NCBI Synonym Full Names:caspase recruitment domain family, member 17
NCBI Official Symbol:CARD17  
NCBI Official Synonym Symbols:INCA  
NCBI Protein Information:caspase recruitment domain-containing protein 17; Inhibitory CARD; caspase-1 inhibitor INCA; inhibitory caspase recruitment domain (CARD) protein; inhibitory caspase recruitment domain protein
UniProt Protein Name:Caspase recruitment domain-containing protein 17
UniProt Synonym Protein Names:Caspase-1 inhibitor INCA; Inhibitory caspase recruitment domain protein
Protein Family:Inclusion membrane protein
UniProt Gene Name:CARD17  
UniProt Entry Name:CAR17_HUMAN
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