Human CAMP Recombinant Protein (RPPB2975)

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SKU:
RPPB2975
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CAMP
Synonyms:
CAP-18
Synonyms:
CAP18
Synonyms:
CRAMP
Synonyms:
FALL-39
Source:
Escherichia Coli
Uniprot:
P49913
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Description

Product Name:Human CAMP Recombinant Protein
Product Code:RPPB2975
Size:10µg
Species:Human
Target:CAMP
Synonyms:CAP-18, CAP18, CRAMP, FALL-39, FALL39, HSD26, LL37, 18 kDa cationic antimicrobial protein, FALL-39 peptide antibiotic, Cathelicidin antimicrobial peptide.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CAMP protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQVLSYKE AVLRAIDGIN QRSSDANLYR LLDLDPRPTM DGDPDTPKPV SFTVKETVCP RTTQQSPEDC DFKKDGLVKR CMGTVTLNQA RGSFDISCDK DNKRFALLGD FFRKSKEKIG KEFKRIVQRI KDFLRNLVPR TES

CAMP belongs to the antimicrobial peptide family, contains highly conserved N-terminal signal peptide, a cathelin domain and a structurally variable cationic antimicrobial peptide that produced by extracellular proteolysis from the C-terminus. CAMP has numerous functions besides the antimicrobial activity such as: cell chemotaxis, immune mediator induction and inflammatory response regulation.

CAMP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 163 amino acids (34-173 a.a.) and having a molecular mass of 18.4kDa.CAMP is fused to a 23 amino acid His-tag at N-terminus.

UniProt Protein Function:CAMP: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. Belongs to the cathelicidin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Cell cycle regulation; Vesicle; Secreted

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cell wall; extracellular region; extracellular space; specific granule

Biological Process: antibacterial humoral response; cell redox homeostasis; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response in mucosa; killing by host of symbiont cells

NCBI Summary:This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
UniProt Code:P49913
NCBI GenInfo Identifier:1706745
NCBI Gene ID:820
NCBI Accession:P49913.1
UniProt Secondary Accession:P49913,Q71SN9,
UniProt Related Accession:P49913
Molecular Weight:19,301 Da
NCBI Full Name:Cathelicidin antimicrobial peptide
NCBI Synonym Full Names:cathelicidin antimicrobial peptide
NCBI Official Symbol:CAMP  
NCBI Official Synonym Symbols:LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39  
NCBI Protein Information:cathelicidin antimicrobial peptide
UniProt Protein Name:Cathelicidin antimicrobial peptide
UniProt Synonym Protein Names:FALL-39 peptide antibiotic
Protein Family:CAMPATH-1 antigen
UniProt Gene Name:CAMP  
UniProt Entry Name:CAMP_HUMAN
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