Human CAMK2N2 Recombinant Protein (RPPB2449)

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SKU:
RPPB2449
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CAMK2N2
Synonyms:
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Synonyms:
CAMK2N2
Synonyms:
CaM-KII inhibitory protein
Synonyms:
CaM-KIIN
Source:
Escherichia Coli
Uniprot:
Q96S95
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Description

Product Name:Human CAMK2N2 Recombinant Protein
Product Code:RPPB2449
Size:20µg
Species:Human
Target:CAMK2N2
Synonyms:Calcium/calmodulin-dependent protein kinase II inhibitor 2, CAMK2N2, CaM-KII inhibitory protein, CaM-KIIN, CAMKIIN, Calcium/calmodulin-dependent protein kinase II.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CAMK2N2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSEILPY SEDKMGRFGA DPEGSDLSFS CRLQDTNSFF AGNQAKRPPK LGQIGRAKRV VIEDDRIDDV LKGMGEKPPS GV

Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 (CAMK2N2) is a protein coding gene which regulates cell growth when overexpressed in colon adenocarcinoma LoVo cells. CAMK2N2 plays a role as a cellular inhibitor of CaM-kinase II (CAMK2).

CAMK2N2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 102 amino acids (1-79a.a) and having a molecular mass of 11kDa.CAMK2N2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CAMK2N2: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2. Belongs to the CAMK2N family.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Inhibitor

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: centrosome; cytosol; nucleus

Molecular Function:calcium-dependent protein kinase inhibitor activity; protein kinase binding

NCBI Summary:This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]
UniProt Code:Q96S95
NCBI GenInfo Identifier:15147234
NCBI Gene ID:94032
NCBI Accession:NP_150284.1
UniProt Related Accession:Q96S95
Molecular Weight:8,658 Da
NCBI Full Name:calcium/calmodulin-dependent protein kinase II inhibitor 2
NCBI Synonym Full Names:calcium/calmodulin dependent protein kinase II inhibitor 2
NCBI Official Symbol:CAMK2N2  
NCBI Official Synonym Symbols:CAMKIIN; CAM-KIIN  
NCBI Protein Information:calcium/calmodulin-dependent protein kinase II inhibitor 2
UniProt Protein Name:Calcium/calmodulin-dependent protein kinase II inhibitor 2
UniProt Synonym Protein Names:CaM-KII inhibitory protein; CaM-KIIN
Protein Family:Calcium/calmodulin-dependent protein kinase II inhibitor
UniProt Gene Name:CAMK2N2  
UniProt Entry Name:CK2N2_HUMAN
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