Human BRD1 Recombinant Protein (RPPB2906)

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SKU:
RPPB2906
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
BRD1
Synonyms:
Bromodomain Containing 1
Synonyms:
BRL
Synonyms:
Bromodomain And PHD Finger-Containing Protein2
Synonyms:
BR140-Like Protein
Source:
Escherichia Coli
Uniprot:
O95696
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Description

Product Name:Human BRD1 Recombinant Protein
Product Code:RPPB2906
Size:20µg
Species:Human
Target:BRD1
Synonyms:Bromodomain Containing 1, BRL, Bromodomain And PHD Finger-Containing Protein2, BR140-Like Protein, BRPF2, Bromodomain-Containing Protein 1, Bromodomain-Containing 1, BR140-Like, BRPF1, BRD1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:BRD1 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEQVAMEL RLTPLTVLLR SVLDQLQDKD PARIFAQPVS LKEVPDYLDH IKHPMDFATM RKRLEAQGYK NLHEFEEDFD LIIDNCMKYN ARDTVFYRAA VRLRDQGGVV LRQARREVDS IGLEEASGMH LPERPA

Bromodomain Containing 1 also known as BRD1 contains a bromodomain,which is a sequence motif frequently found in transcriptional coactivators, andlocalizes to the nucleus in testis and several other cell types. Variations in BRD1are connected with schozophrenia & bipolar disorder.

BRD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (556-688 a.a) and having a molecular mass of 17.8kDa.BRD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:BRD1: a nuclear protein containing a bromo-domain, a PHD domain, and a PWWP domain. Encoded by a susceptibility gene for schizophrenia and bipolar affective disorder. May play a role in neurodevelopment.
UniProt Protein Details:

Protein type:Cell development/differentiation

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: nucleoplasm; nucleus

Molecular Function:histone binding

NCBI Summary:This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Code:O95696
NCBI GenInfo Identifier:12229697
NCBI Gene ID:23774
NCBI Accession:O95696.1
UniProt Secondary Accession:O95696,A6ZJA4,
UniProt Related Accession:O95696
Molecular Weight:133,243 Da
NCBI Full Name:Bromodomain-containing protein 1
NCBI Synonym Full Names:bromodomain containing 1
NCBI Official Symbol:BRD1  
NCBI Official Synonym Symbols:BRL; BRPF1; BRPF2  
NCBI Protein Information:bromodomain-containing protein 1
UniProt Protein Name:Bromodomain-containing protein 1
UniProt Synonym Protein Names:BR140-like protein; Bromodomain and PHD finger-containing protein 2
UniProt Gene Name:BRD1  
UniProt Entry Name:BRD1_HUMAN
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