Human BLOC1S2 Recombinant Protein (RPPB2899)
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주문- SKU:
- RPPB2899
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- BLOC1S2
- Synonyms:
- Biogenesis of lysosomal organelles complex-1 subunit 2
- Synonyms:
- BLOS2
- Synonyms:
- BLOC-1 subunit 2
- Synonyms:
- Centrosome-associated protein
- Source:
- Escherichia Coli
- Uniprot:
- Q6QNY1
Description
| Product Name: | Human BLOC1S2 Recombinant Protein |
| Product Code: | RPPB2899 |
| Size: | 20µg |
| Species: | Human |
| Target: | BLOC1S2 |
| Synonyms: | Biogenesis of lysosomal organelles complex-1 subunit 2, BLOS2, BLOC-1 subunit 2, Centrosome-associated protein, centrosome protein oncogene, centrosomal 10 kDa protein, RP11-316M21.4, CEAP, FLJ30135, MGC10120. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The BLOC1S2 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 50mM NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAAAAE GVLATRSDEP ARDDAAVETA EEAKEPAEAD ITELCRDMFS KMATYLTGEL TATSEDYKLL ENMNKLTSLK YLEMKDIAIN ISRNLKDLNQ KYAGLQPYLD QINVIEEQVA ALEQAAYKLD AYSKKLEAKY KKLEKR |
BLOC1S2 is a member of the BLOC1S2 family. Biogenesis of lysosome-related organelles complex 1 or BLOC-1 is a universally expressed multisubunit protein complex which is essential for regular biogenesis of specialized organelles of the endosomal-lysosomal system, like melanosomes and platelet dense granules. BLOC1S2 takes part in cell proliferation.
BLOC1S2 Human Recombinant produced in E. coli is a single polypeptide chain containing 166 amino acids (1-142) and having a molecular mass of 18.5kDa.BLOC1S2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BLOC1S2: May play a role in cell proliferation. The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Belongs to the BLOC1S2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q24.31 Cellular Component: centrosome; recycling endosome; mitochondrion; nucleus; gamma-tubulin complex Molecular Function:protein C-terminus binding; protein binding; gamma-tubulin binding Biological Process: induction of apoptosis via death domain receptors; platelet dense granule organization and biogenesis; melanosome organization and biogenesis; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; anterograde synaptic vesicle transport; positive regulation of transcription from RNA polymerase II promoter; microtubule nucleation; anterograde axon cargo transport; neurite development |
| NCBI Summary: | This gene encodes a protein with multiple functions. The encoded protein has been found in association with the centrosome, shown to co-localize with gamma-tubulin, and also found to be one of the proteins in the BLOC-1 complex which functions in the formation of lysosome-related organelles. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q6QNY1 |
| NCBI GenInfo Identifier: | 47717129 |
| NCBI Gene ID: | 282991 |
| NCBI Accession: | NP_001001342.1 |
| UniProt Secondary Accession: | Q6QNY1,Q9CWG9, Q32WR5, |
| UniProt Related Accession: | Q6QNY1 |
| Molecular Weight: | 11,489 Da |
| NCBI Full Name: | biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 2 |
| NCBI Synonym Full Names: | biogenesis of lysosomal organelles complex-1, subunit 2 |
| NCBI Official Symbol: | BLOC1S2 |
| NCBI Official Synonym Symbols: | CEAP; BLOS2; CEAP11 |
| NCBI Protein Information: | biogenesis of lysosome-related organelles complex 1 subunit 2; 11 kDa centrosome associated protein; BLOC-1 subunit 2; centrosomal 10 kDa protein; centrosome protein oncogene |
| UniProt Protein Name: | Biogenesis of lysosome-related organelles complex 1 subunit 2 |
| UniProt Synonym Protein Names: | Centrosome-associated protein |
| Protein Family: | Biogenesis of lysosome-related organelles complex |
| UniProt Gene Name: | BLOC1S2 |
| UniProt Entry Name: | BL1S2_HUMAN |
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