Human BEX1 Recombinant Protein (RPPB2885)

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SKU:
RPPB2885
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
BEX1
Synonyms:
BEX2
Synonyms:
HBEX2
Synonyms:
HGR74-h
Synonyms:
Protein BEX1
Source:
Escherichia Coli
Uniprot:
Q9HBH7
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Description

Product Name:Human BEX1 Recombinant Protein
Product Code:RPPB2885
Size:10µg
Species:Human
Target:BEX1
Synonyms:BEX2, HBEX2, HGR74-h, Protein BEX1, Brain-expressed X-linked protein 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The BEX1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMESKEKR AVNSLSMENA NQENEEKEQV ANKGEPLALP LDAGEYCVPR GNRRRFRVRQ PILQYRWDMM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH HDEFCLMP

Brain Expressed X-Linked 1 (BEX1) which participates in cell cycle progression and neuronal differentiation, is a signaling adapter molecule involved in p75NTR/NGFR signaling. BEX1 inhibits neuronal differentiation in response to nerve growth factor. BEX1 links between the cell cycle and neurotrophic factor signaling by acting as an upstream modulator of receptor signaling, adjusting biological responses to external signals with internal cellular states.

BEX1 Human Recombinant produced in E. coli is a single polypeptide chain containing 148 amino acids (1-125) and having a molecular mass of 17.2kDa. BEX1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:BEX1: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. Belongs to the BEX family.Protein type: Cell development/differentiation; Cell cycle regulationChromosomal Location of Human Ortholog: Xq22.1|Xq22Cellular Component: transcription factor complexMolecular Function: protein bindingBiological Process: positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9HBH7
NCBI GenInfo Identifier:91208332
NCBI Gene ID:55859
NCBI Accession:Q9HBH7.2
UniProt Secondary Accession:Q9HBH7,Q9NZ33, A0AVN1, A8K4J3
UniProt Related Accession:Q9HBH7
Molecular Weight:14,860 Da
NCBI Full Name:Protein BEX1
NCBI Synonym Full Names:brain expressed X-linked 1
NCBI Official Symbol:BEX1  
NCBI Official Synonym Symbols:BEX2; HBEX2; HGR74-h  
NCBI Protein Information:protein BEX1
UniProt Protein Name:Protein BEX1
UniProt Synonym Protein Names:Brain-expressed X-linked protein 1
Protein Family:Protein
UniProt Gene Name:BEX1  
UniProt Entry Name:BEX1_HUMAN
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