Human BDH2 Recombinant Protein (RPPB1442)

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주문
SKU:
RPPB1442
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
BDH2
Synonyms:
3-hydroxybutyrate dehydrogenase type 2
Synonyms:
FLJ13261
Synonyms:
PRO20933
Synonyms:
SDR15C1
Source:
Escherichia Coli
Uniprot:
Q9BUT1
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Description

Product Name:Human BDH2 Recombinant Protein
Product Code:RPPB1442
Size:20µg
Species:Human
Target:BDH2
Synonyms:3-hydroxybutyrate dehydrogenase type 2, FLJ13261, PRO20933, SDR15C1, UCPA-OR, UNQ6308, dehydrogenase/reductase (SDR family) member 6, Oxidoreductase UCPA, DHRS6, R-beta-hydroxybutyrate dehydrogenase, EFA6R, EC 1.1.1.30.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The BDH2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL

BDH2 is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH2 protein has a significant part in the peripheral utilization of 3-hydroxybutyrate. BDH2 can convert high levels of circulating 3-hydroxybutyrate into acetoacetate due to cytoplasmic localization in high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters.

BDH2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-245a.a.) and having a molecular mass of 28.8kDa.BDH2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9BUT1
NCBI GenInfo Identifier:66933014
NCBI Gene ID:56898
NCBI Accession:NP_064524
UniProt Secondary Accession:Q9BUT1,Q503A0, Q6IA46, Q6UWD3, Q9H8S8, Q9NRX8, A8K295 B4DUF6
UniProt Related Accession:Q9BUT1
Molecular Weight:28.8 kDa (265aa), confirmed by MALDI-TOF
NCBI Full Name:3-hydroxybutyrate dehydrogenase type 2
NCBI Synonym Full Names:3-hydroxybutyrate dehydrogenase 2
NCBI Official Symbol:BDH2  
NCBI Official Synonym Symbols:DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933  
NCBI Protein Information:3-hydroxybutyrate dehydrogenase type 2
UniProt Protein Name:3-hydroxybutyrate dehydrogenase type 2
UniProt Synonym Protein Names:Dehydrogenase/reductase SDR family member 6; Oxidoreductase UCPA; R-beta-hydroxybutyrate dehydrogenase; Short chain dehydrogenase/reductase family 15C member 1
Protein Family:Probable diacetyl reductase
UniProt Gene Name:BDH2  
UniProt Entry Name:
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