Human B9D2 Recombinant Protein (RPPB2841)

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SKU:
RPPB2841
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
B9D2
Synonyms:
B9 Protein Domain 2
Synonyms:
B9D2
Synonyms:
B9 domain-containing protein 2
Synonyms:
MKS1-related protein 2
Source:
Escherichia Coli
Uniprot:
Q9BPU9
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Description

Product Name:Human B9D2 Recombinant Protein
Product Code:RPPB2841
Size:10µg
Species:Human
Target:B9D2
Synonyms:B9 Protein Domain 2, B9D2, B9 domain-containing protein 2, MKS1-related protein 2, MKSR2, ICIS-1, MKS10.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The B9D2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT and 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAEVHVI GQIIGASGFS ESSLFCKWGI HTGAAWKLLS GVREGQTQVD TPQIGDMAYW SHPIDLHFAT KGLQGWPRLH FQVWSQDSFG RCQLAGYGFC HVPSSPGTHQ LACPTWRPLG SWREQLARAF VGGGPQLLHG DTIYSGADRY RLHTAAGGTV HLEIGLLLRN FDRYGVEC

B9 Protein Domain 2 (B9D2) is a component of the tectonic-like complex which acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. B9D2 contains a B9 domain protein, which is found solely in ciliated organisms. B9D2 is upregulated throughout mucociliary differentiation.

B9D2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (1-175) and having a molecular mass of 21.6 kDa.B9D2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:B9D2: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Defects in B9D2 are the cause of Meckel syndrome type 10 (MKS10). MKS10 is a disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Belongs to the B9D family.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: centrosome; cytosol

Molecular Function:gamma-tubulin binding; protein binding

Biological Process: sister chromatid cohesion

Disease: Meckel Syndrome, Type 10

NCBI Summary:This gene encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting expression of this gene results in ciliogenesis defects. [provided by RefSeq, Oct 2009]
UniProt Code:Q9BPU9
NCBI GenInfo Identifier:226371646
NCBI Gene ID:80776
NCBI Accession:NP_085055
UniProt Related Accession:Q9BPU9
Molecular Weight:19kDa
NCBI Full Name:B9 domain-containing protein 2
NCBI Synonym Full Names:B9 domain containing 2
NCBI Official Symbol:B9D2  
NCBI Official Synonym Symbols:MKS10; MKSR2; ICIS-1; JBTS34  
NCBI Protein Information:B9 domain-containing protein 2
UniProt Protein Name:B9 domain-containing protein 2
UniProt Synonym Protein Names:MKS1-related protein 2
Protein Family:B9 domain-containing protein
UniProt Gene Name:B9D2  
UniProt Entry Name:B9D2_HUMAN
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