Human ATP6V1F Recombinant Protein (RPPB2827)

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주문
SKU:
RPPB2827
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
ATP6V1F
Synonyms:
ATP6S14
Synonyms:
VATF
Synonyms:
Vma7
Synonyms:
V-type proton ATPase subunit F
Source:
Escherichia Coli
Uniprot:
Q16864
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Description

Product Name:Human ATP6V1F Recombinant Protein
Product Code:RPPB2827
Size:20µg
Species:Human
Target:ATP6V1F
Synonyms:ATP6S14, VATF, Vma7, V-type proton ATPase subunit F, V-ATPase14 kDa subunit.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:ATP6V1F protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 50% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAGRGKL IAVIGDEDTV TGFLLGGIGE LNKNRHPNFL VVEKDTTINEIEDTFRQFLN RDDIGIILIN QYIAEMVRHA LDAHQQSIPA VLEIPSKEHP YDAAKDSILR RARGMFTAED LR

ATPase Transporting, Lysosomal V1 Subunit F (ATP6V1F) is a component of vacuolar ATPase (V-ATPase); it is a multi-subunit enzyme, which mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is required for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain contains 3 A and 3 B subunits, 2 G subunits as well as the C, D, E, F, and H subunits. The V1 domain has the ATP catalytic site. The V0 domain consists of 5 different subunits: a, c, c', c', and d.

ATP6V1F Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 142 amino acids (1-119 a.a) and having a molecular mass of 15.8kDa.ATP6V1F is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ATP6V1F: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase F subunit family.Protein type: HydrolaseChromosomal Location of Human Ortholog: 7q32Cellular Component: cytosol; membrane; vacuolar proton-transporting V-type ATPase complexMolecular Function: ATPase activity, coupled to transmembrane movement of ions; protein bindingBiological Process: insulin receptor signaling pathway; transferrin transport
UniProt Protein Details:
NCBI Summary:This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]
UniProt Code:Q16864
NCBI GenInfo Identifier:126302612
NCBI Gene ID:9296
NCBI Accession:Q16864.2
UniProt Secondary Accession:Q16864,Q6IBA8, C9J2K4
UniProt Related Accession:Q16864
Molecular Weight:16,402 Da
NCBI Full Name:V-type proton ATPase subunit F
NCBI Synonym Full Names:ATPase H+ transporting V1 subunit F
NCBI Official Symbol:ATP6V1F  
NCBI Official Synonym Symbols:VATF; Vma7; ATP6S14  
NCBI Protein Information:V-type proton ATPase subunit F
UniProt Protein Name:V-type proton ATPase subunit F
UniProt Synonym Protein Names:V-ATPase 14 kDa subunit; Vacuolar proton pump subunit F
Protein Family:
UniProt Gene Name:ATP6V1F  
UniProt Entry Name:VATF_HUMAN
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