Human ATP1B3 Recombinant Protein (RPPB2822)

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SKU:
RPPB2822
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ATP1B3
Synonyms:
ATPase Na+/K+ Transporting Beta 3 Polypeptide
Synonyms:
Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic)
Synonyms:
Sodium/Potassium-Transporting ATPase Subunit Beta-3
Synonyms:
Sodium/Potassium-Dependent ATPase Subunit Beta-3
Source:
Escherichia Coli
Uniprot:
P54709
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Description

Product Name:Human ATP1B3 Recombinant Protein
Product Code:RPPB2822
Size:10µg
Species:Human
Target:ATP1B3
Synonyms:ATPase Na+/K+ Transporting Beta 3 Polypeptide, Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic), Sodium/Potassium-Transporting ATPase Subunit Beta-3, Sodium/Potassium-Dependent ATPase Subunit Beta-3, Sodium Pump Subunit Beta-3, ATPB-3, Sodium/Potassium-Transporting ATPase Beta-3 Chain, Sodium/Potassium-Dependent ATPase Beta-3 Subunit, Na K-ATPase Beta-3 Polypeptide, CD298 Antigen, CD298, ATP1B3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ATP1B3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 0.15M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSTMWVMLQ TLNDEVPKYR DQIPSPGLMV FPKPVTALEY TFSRSDPTSY AGYIEDLKKF LKPYTLEEQK NLTVCPDGAL FEQKGPVYVA CQFPISLLQA CSGMNDPDFG YSQGNPCILV KMNRIIGLKP EGVPRIDCVS KNEDIPNVAV YPHNGMIDLK YFPYYGKKLH VGYLQPLVAV QVSFAPNNTG KEVTVECKID GSANLKSQDD RDKFLGRVMF KITARA

ATPaseTransporting Beta 3 (ATP1B3) is a member of the X(+)/potassium ATPases subunit beta family. ATP1B3 is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit controls, by way of assembly of alpha/beta heterodimers, the quantity of sodium pumps transported to the plasma membrane. The precise role of the beta-3 subunit is unknown.

ATP1B3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 246 amino acids (57-279) and having a molecular mass of 27.4 kDa.ATP1B3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ATP1B3: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family.Protein type: Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 3q23Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complexMolecular Function: ATPase activator activity; ATPase binding; sodium:potassium-exchanging ATPase activityBiological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]
UniProt Code:P54709
NCBI GenInfo Identifier:1703470
NCBI Gene ID:483
NCBI Accession:P54709.1
UniProt Secondary Accession:P54709,B7Z1N7
UniProt Related Accession:P54709
Molecular Weight:21,713 Da
NCBI Full Name:Sodium/potassium-transporting ATPase subunit beta-3
NCBI Synonym Full Names:ATPase Na+/K+ transporting subunit beta 3
NCBI Official Symbol:ATP1B3  
NCBI Official Synonym Symbols:CD298; ATPB-3  
NCBI Protein Information:sodium/potassium-transporting ATPase subunit beta-3
UniProt Protein Name:Sodium/potassium-transporting ATPase subunit beta-3
UniProt Synonym Protein Names:Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD_antigen: CD298
Protein Family:
UniProt Gene Name:ATP1B3  
UniProt Entry Name:AT1B3_HUMAN
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