Human ASPSCR1 Recombinant Protein (RPPB2809)

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SKU:
RPPB2809
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ASPSCR1
Synonyms:
ASPCR1
Synonyms:
ASPL
Synonyms:
ASPS
Synonyms:
RCC17
Source:
Escherichia Coli
Uniprot:
Q9BZE9
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Description

Product Name:Human ASPSCR1 Recombinant Protein
Product Code:RPPB2809
Size:10µg
Species:Human
Target:ASPSCR1
Synonyms:ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9, Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9, ASPSCR1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The ASPSCR1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAAPAGG GGSAVSVLAP NGRRHTVKVT PSTVLLQVLE DTCRRQDFNP CEYDLKFQRS VLDLSLQWRF ANLPNNAKLE MVPASRSREG PENMVRIALQ LDDGSRLQDS FCSGQTLWEL LSHFPQIREC LQHPGGATPV CVYTRDEVTG EAALRGTTLQ SLGLTGGSAT IRFVMKCYDP VGKTPGSLGS SASAGQAAAS APLPLESGEL SRGDLSRPED ADTSGPCCEH TQEKQSTRAP AAAPFVPFSG GGQRLGGPPG PTRPLTSSSA KLPKSLSSPG GPSKPKKSKS GQDPQQEQEQ ERERDPQQEQ ERERPVDREP VDREPVVCHP DLEERLQAWP AELPDEFFEL TVDDVRRRLA QLKSERKRLE EAPLVTKAFR EAQIKEKLER YPKVALRVLF PDRYVLQGFF RPSETVGDLR DFVRSHLGNP ELSFYLFITP PKTVLDDHTQ TLFQANLFPA ALVHLGAEEP AGVYLEPGLL EHAISPSAAD VLVARYMSRA AGSPSPLPAP DPAPKSEPAA EEGALVPPEP IPGTAQPVKR SLGKVPKWLK LPASKR

Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). ASPSCR1 is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells, and redistributes the GLUT4 to the plasma membrane. Translocation t(X;17)(p11;q25) of this ASPSCR1 with transcription factor TFE3 gene ends with a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas.

ASPSCR1 Human Recombinant produced in E. coli is a single polypeptide chain containing 576 amino acids (1-553) and having a molecular mass of 62.6kDa. ASPSCR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ASPSCR1: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oncoprotein; Membrane protein, peripheral; Vesicle

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function:protein binding

Disease: Alveolar Soft Part Sarcoma

NCBI Summary:The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
UniProt Code:Q9BZE9
NCBI GenInfo Identifier:74717746
NCBI Gene ID:79058
NCBI Accession:Q9BZE9.1
UniProt Secondary Accession:Q9BZE9,Q7Z6N7, Q8WV59, Q96LS5, Q96M40, A8K3K9,
UniProt Related Accession:Q9BZE9
Molecular Weight:37,910 Da
NCBI Full Name:Tether containing UBX domain for GLUT4
NCBI Synonym Full Names:ASPSCR1, UBX domain containing tether for SLC2A4
NCBI Official Symbol:ASPSCR1  
NCBI Official Synonym Symbols:TUG; ASPL; ASPS; RCC17; UBXD9; UBXN9; ASPCR1  
NCBI Protein Information:tether containing UBX domain for GLUT4
UniProt Protein Name:Tether containing UBX domain for GLUT4
UniProt Synonym Protein Names:Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9
Protein Family:Tether containing UBX domain
UniProt Gene Name:ASPSCR1  
UniProt Entry Name:ASPC1_HUMAN
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