Human ASB8 Recombinant Protein (RPPB2802)

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SKU:
RPPB2802
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ASB8
Synonyms:
Ankyrin Repeat And SOCS Box Containing 8
Synonyms:
ASB-8
Source:
Escherichia Coli
Uniprot:
Q9H765
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Description

Product Name:Human ASB8 Recombinant Protein
Product Code:RPPB2802
Size:10µg
Species:Human
Target:ASB8
Synonyms:Ankyrin Repeat And SOCS Box Containing 8, ASB-8.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The ASB8 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSSSMWY IMQSIQSKYS LSERLIRTIA AIRSFPHDNV EDLIRGGADV NCTHGTLKPL HCACMVSDAD CVELLLEKGA EVNALDGYNR TALHYAAEKD EACVEVLLEY GANPNALDGN RDTPLHWAAF KNNAECVRAL LESGASVNAL DYNNDTPLSW AAMKGNLESV SILLDYGAEV RVINLIGQTP ISRLVALLVR GLGTEKEDSC FELLHRAVGH FELRKNGTMP REVARDPQLC EKLTVLCSAP GTLKTLARYA VRRSLGLQYL PDAVKGLPLP ASLKEYLLLL E

ASB8 is a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex that facilitates the ubiquitination and consequent proteasomal degradation of objective proteins.

ASB8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 311 amino acids (1-288) and having a molecular mass of 34.0kDa.ASB8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ASB8: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.Chromosomal Location of Human Ortholog: 12q13.11Cellular Component: cytoplasmBiological Process: protein ubiquitination
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9H765
NCBI GenInfo Identifier:13129098
NCBI Gene ID:140461
NCBI Accession:NP_077000
UniProt Secondary Accession:Q9H765,Q547Q2, A8K1P2
UniProt Related Accession:Q9H765
Molecular Weight:34.0 kDa (311aa) confirmed by MALDI-TOF
NCBI Full Name:ankyrin repeat and SOCS box protein 8 isoform a
NCBI Synonym Full Names:ankyrin repeat and SOCS box containing 8
NCBI Official Symbol:ASB8  
NCBI Official Synonym Symbols:PP14212  
NCBI Protein Information:ankyrin repeat and SOCS box protein 8
UniProt Protein Name:Ankyrin repeat and SOCS box protein 8
UniProt Synonym Protein Names:
Protein Family:Ankyrin repeat and SOCS box protein
UniProt Gene Name:ASB8  
UniProt Entry Name:ASB8_HUMAN
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