Human ASB13 Recombinant Protein (RPPB2803)
- SKU:
- RPPB2803
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- ASB13
- Synonyms:
- Ankyrin repeat and SOCS box protein 13
- ASB-13
- ASB13
- ankyrin repeat and SOCS box containing 13
- Source:
- Escherichia Coli
- Uniprot:
- Q8WXK3
Description
| Product Name: | Human ASB13 Recombinant Protein |
| Product Code: | RPPB2803 |
| Size: | 20µg |
| Species: | Human |
| Target: | ASB13 |
| Synonyms: | Ankyrin repeat and SOCS box protein 13, ASB-13, ASB13, ankyrin repeat and SOCS box containing 13. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ASB13 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEPRAAD GCFLGDVGFW VERTPVHEAA QRGESLQLQQ LIESGACVNQ VTVDSITPLH AASLQGQARC VQLLLAAGAQ VDARNIDGST PLCDACASGS IECVKLLLSY GAKVNPPLYT ASPLHEACMS GSSECVRLLI DVGANLEAHD CHFGTPLHVA CAREHLDCVK VLLNAGANVN AAKLHETALH HAAKVKNVDL IEMLIEFGGN IYARDNRGKK PSDYTWSSSA PAKCFEYYEK TPLTLSQLCR VNLRKATGVR GLEKIAKLNI PPRLIDYLSY N |
ASB13 belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins which contains ankyrin repeat sequence and a SOCS box domain. ASB13 is a protein coding gene that plays a role as a substrate-recognition part of a SCF-like ECS E3 ubiquitin-protein ligase complex which arbitrates the ubiquitination and subsequent proteasomal degradation of target proteins.
ASB13 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 301 amino acids (1-278 a.a.) and having a molecular mass of 32.4kDa.ASB13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ASB13: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10p15.1 Molecular Function:protein binding Biological Process: protein ubiquitination |
| NCBI Summary: | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q8WXK3 |
| NCBI GenInfo Identifier: | 22208957 |
| NCBI Gene ID: | 79754 |
| NCBI Accession: | NP_078977.2 |
| UniProt Secondary Accession: | Q8WXK3,Q96EP7, Q9H8Z1, A8K7Q6, D3DRR2, |
| UniProt Related Accession: | Q8WXK3 |
| Molecular Weight: | 18,205 Da |
| NCBI Full Name: | ankyrin repeat and SOCS box protein 13 |
| NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 13 |
| NCBI Official Symbol: | ASB13 |
| NCBI Protein Information: | ankyrin repeat and SOCS box protein 13; ankyrin repeat and SOCS box-containing 13; ankyrin repeat domain-containing SOCS box protein Asb-13 |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 13 |
| Protein Family: | Ankyrin repeat and SOCS box protein |
| UniProt Gene Name: | ASB13 |
| UniProt Entry Name: | ASB13_HUMAN |
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