Human ARL1 Recombinant Protein (RPPB2783)
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주문- SKU:
- RPPB2783
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- ARL1
- Synonyms:
- ARFL1
- Source:
- Escherichia Coli
- Uniprot:
- P40616
Description
| Product Name: | Human ARL1 Recombinant Protein |
| Product Code: | RPPB2783 |
| Size: | 20µg |
| Species: | Human |
| Target: | ARL1 |
| Synonyms: | ARFL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The ARL1 solution (0.25mg/ml) containing 20mM Tris-HCl pH-8, 2mM DTT, 100mM NaCl and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGGFFSSIFS SLFGTREMRI LILGLDGAGK TTILYRLQVG EVVTTIPTIG FNVETVTYKN LKFQVWDLGG QTSIRPYWRC YYSNTDAVIY VVDSCDRDRI GISKSELVAM LEEEELRKAI LVVFANKQDM EQAMTSSEMA NSLGLPALKD RKWQIFKTSA TKGTGLDEAM EWLVETLKSR Q |
ARL1 is part of the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally associated to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, control intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. ARL1 is a weak stimulator of PLD and CT in a phospholipid dependent manner. ARL1 is a GTP-binding protein that has low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. ARL1 is involved in the Golgi apparatus.
ARL1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 201 amino acids (1-181 a.a.) and having a molecular mass of 22.5 kDa. The ARL1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ARL1: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric; G protein, monomeric, ARF Chromosomal Location of Human Ortholog: 12q23.2 Cellular Component: Golgi membrane; Golgi apparatus; cytoplasm; trans-Golgi network Molecular Function:GTPase activity; protein domain specific binding; GTP binding; metal ion binding; enzyme activator activity Biological Process: phospholipase D activation; toxin metabolic process; protein localization in Golgi apparatus; small GTPase mediated signal transduction; retrograde transport, endosome to Golgi; Golgi organization and biogenesis; Golgi vesicle transport |
| NCBI Summary: | The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P40616 |
| NCBI GenInfo Identifier: | 728888 |
| NCBI Gene ID: | 400 |
| NCBI Accession: | P40616.1 |
| UniProt Related Accession: | P40616 |
| Molecular Weight: | 20kDa |
| NCBI Full Name: | ADP-ribosylation factor-like protein 1 |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 1 |
| NCBI Official Symbol: | ARL1 |
| NCBI Official Synonym Symbols: | ARFL1 |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 1 |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 1 |
| Protein Family: | ARL14 effector protein |
| UniProt Gene Name: | ARL1 |
| UniProt Entry Name: | ARL1_HUMAN |
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