Human ANKRD1 Recombinant Protein (RPPB2742)

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SKU:
RPPB2742
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ANKRD1
Synonyms:
Ankyrin Repeat Domain 1 (Cardiac Muscle)
Synonyms:
Cardiac Ankyrin Repeat Protein
Synonyms:
Cytokine-Inducible Gene C-193 Protein
Synonyms:
Ankyrin Repeat Domain-Containing Protein 1
Source:
Escherichia Coli
Uniprot:
Q15327
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Description

Product Name:Human ANKRD1 Recombinant Protein
Product Code:RPPB2742
Size:10µg
Species:Human
Target:ANKRD1
Synonyms:Ankyrin Repeat Domain 1 (Cardiac Muscle), Cardiac Ankyrin Repeat Protein, Cytokine-Inducible Gene C-193 Protein, Ankyrin Repeat Domain-Containing Protein 1, Cytokine-Inducible Nuclear Protein, Liver Ankyrin Repeat Domain 1, BA320F15.2, CARP, ALRP, CVARP, MCARP, HA1A2, C193.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ANKRD1 solution contains 20mM Tris-HCl buffer (pH 8.5), 0.2M NaCl, 5mM DTT and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGS MMVLKVE ELVTGKKNGN GEAGEFLPED FRDGEYEAAV TLEKQEDLKT LLAHPVTLGE QQWKSEKQRE AELKKKKLEQ RSKLENLEDL EIIIQLKKRK KYRKTKVPVV KEPEPEIITE PVDVPTFLKA ALENKLPVVE KFLSDKNNPD VCDEYKRTAL HRACLEGHLA IVEKLMEAGA QIEFRDMLES TAIHWASRGG NLDVLKLLLN KGAKISARDK LLSTALHVAV RTGHYECAEH LIACEADLNA KDREGDTPLH DAVRLNRYKM IRLLIMYGAD LNIKNCAGKT PMDLVLHWQN GTKAIFDSLR ENSYKTSRIA TF

ANKRD1 takes part in endothelial cell activation and performs as a nuclear transcription factor which negatively controls the expression of cardiac genes.

ANKRD1 Human Recombinant produced in E. coli is a single polypeptide chain containing 342 amino acids (1-319) and having a molecular mass of 38.6 kDa.ANKRD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ANKRD1: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR). TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: cytoplasm; cytosol; I band; nucleolus; nucleoplasm; nucleus; sarcomere

Molecular Function:DNA binding; histone deacetylase binding; p53 binding; protein binding; titin binding; transcription corepressor activity

Biological Process: cardiac muscle morphogensis; muscle cell differentiation; positive regulation of apoptosis; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein secretion

NCBI Summary:The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008]
UniProt Code:Q15327
NCBI GenInfo Identifier:109940213
NCBI Gene ID:27063
NCBI Accession:Q15327.2
UniProt Secondary Accession:Q15327,Q96LE7,
UniProt Related Accession:Q15327
Molecular Weight:36,252 Da
NCBI Full Name:Ankyrin repeat domain-containing protein 1
NCBI Synonym Full Names:ankyrin repeat domain 1
NCBI Official Symbol:ANKRD1  
NCBI Official Synonym Symbols:ALRP; CARP; C-193; CVARP; MCARP; bA320F15.2  
NCBI Protein Information:ankyrin repeat domain-containing protein 1
UniProt Protein Name:Ankyrin repeat domain-containing protein 1
UniProt Synonym Protein Names:Cardiac ankyrin repeat protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein
Protein Family:Ankyrin repeat domain-containing protein
UniProt Gene Name:ANKRD1  
UniProt Entry Name:ANKR1_HUMAN
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