Human AMPD2 Recombinant Protein (RPPB1400)

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SKU:
RPPB1400
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
AMPD2
Synonyms:
(Isoform L)
Synonyms:
EC 3546
Synonyms:
SPG63
Synonyms:
AMP Deaminase Isoform L
Source:
Escherichia Coli
Uniprot:
Q01433
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Description

Product Name:Human AMPD2 Recombinant Protein
Product Code:RPPB1400
Size:10µg
Species:Human
Target:AMPD2
Synonyms:(Isoform L), EC 3.5.4.6, SPG63, AMP Deaminase Isoform L, AMP Deaminase 2, AMPD Isoform L, AMPD, PCH9, AMP deaminase 2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:AMPD2 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by Analysis by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSDLLDAAK SVVRALFIRE KYMALSLQSF CPTTRRYLQQ LAEKPLETRT YEQGPDTPVSADAPVHPPAL EQHPYEHCEP STMPGDLGLG LRMVRGVVHV YTRREPDEHC SEVELPYPDL QEFVADVNVLMALIINGPIK SFCYRRLQYL SSKFQMHVLLNEMKELAAQK KVPHRDFYNI RKVDTHIHAS SCMNQKHLLR FIKRAMKRHLEEIVHVEQGR EQTLREVFES MNLTAYDLSV DTLDVHADRN TFHRFDKFNA KYNPIGESVL REIFIKTDNRVSGKYFAHII KEVMSDLEES KYQNAELRLS IYGRSRDEWD KLARWAVMHR VHSPNVRWLVQVPRLFDVYR TKGQLANFQE MLENIFLPLF EATVHPASHP ELHLFLEHVDGFDSVDDESK PENHVFNLES PLPEAWVEED NPPYAYYLYY TFANMAMLNH LRRQRGFHTF VLRPHCGEAGPIHHLVSAFM LAENISHGLL LRKAPVLQYL YYLAQIGIAM SPLSNNSLFL SYHRNPLPEYLSRGLMVSLS TDDPLQFHFT KEPLMEEYSI ATQVWKLSSC DMCELARNSVLMSGFSHKVK SHWLGPNYTK EGPEGNDIRR TNVPDIRVGY RYETLCQELA LITQAVQSEM LETIPEEAGITMSPGPQ

AMPD2 is significant in purine metabolism by converting AMP to IMP. AMPD2 which functions as a homotetramer, is one of the three AMP deaminases shown in mammals. More than a few transcript variants encoding differentisoforms have been discovered for AMPD2.

AMPD2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 667 amino acids (236-879 a.a) andhaving a molecular mass of 77.0kDa.AMPD2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:AMPD2: AMP deaminase plays a critical role in energy metabolism. Belongs to the adenosine and AMP deaminases family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; EC 3.5.4.6; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: cytosol

Molecular Function:AMP deaminase activity; protein binding

Biological Process: IMP biosynthetic process; purine salvage

Disease: Pontocerebellar Hypoplasia, Type 9; Spastic Paraplegia 63, Autosomal Recessive

NCBI Summary:The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:Q01433
NCBI GenInfo Identifier:12644375
NCBI Gene ID:271
NCBI Accession:Q01433.2
UniProt Secondary Accession:Q01433,Q14856, Q14857, Q16686, Q16687, Q16688, Q16729 Q5T693, Q5T695, B4DK50, B4DZI5, E9PNG0,
UniProt Related Accession:Q01433
Molecular Weight:88,288 Da
NCBI Full Name:AMP deaminase 2
NCBI Synonym Full Names:adenosine monophosphate deaminase 2
NCBI Official Symbol:AMPD2  
NCBI Official Synonym Symbols:PCH9; SPG63  
NCBI Protein Information:AMP deaminase 2
UniProt Protein Name:AMP deaminase 2
UniProt Synonym Protein Names:AMP deaminase isoform L
Protein Family:AMP deaminase
UniProt Gene Name:AMPD2  
UniProt Entry Name:AMPD2_HUMAN
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