Human ALPP Recombinant Protein (RPPB1430)

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SKU:
RPPB1430
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
ALPP
Synonyms:
ALP
Synonyms:
PLAP
Synonyms:
Alkaline phosphatase placental type
Synonyms:
EC 3131
Source:
Escherichia Coli
Uniprot:
P05187
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Description

Product Name:Human ALPP Recombinant Protein
Product Code:RPPB1430
Size:5µg
Species:Human
Target:ALPP
Synonyms:ALP, PLAP, Alkaline phosphatase placental type, EC 3.1.3.1, PLAP-1, Alkaline phosphatase Regan isozyme.
Source:Escherichia Coli
Physical Appearance:Sterile filtered liquid.
Formulation:PLAP in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Stability:Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.

Placental alkaline phosphatase (PLAP) is a membrane-associated siaglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. PLAP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It is also commonly expressed in germ cell tumors and more recently described in seminomas.

Placental Alkaline Phosphatase Human Recombinant encoding 154-287 amino acids expressed in E.coli, shows a 41kDa band on SDS-PAGE (including GST tag).PLAP Human Recombinant is purified by proprietary chromatographic techniques.

UniProt Protein Function:ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral; Cofactor and Vitamin Metabolism - folate biosynthesis; Phosphatase (non-protein); Motility/polarity/chemotaxis; Membrane protein, GPI anchor; EC 3.1.3.1

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: cell surface; plasma membrane; integral to membrane

Molecular Function:zinc ion binding; alkaline phosphatase activity; magnesium ion binding

Biological Process: dephosphorylation

NCBI Summary:There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P05187
NCBI GenInfo Identifier:94721246
NCBI Gene ID:250
NCBI Accession:NP_001623.3
UniProt Secondary Accession:P05187,P05188, P06861, Q53S78, Q96DB7,
UniProt Related Accession:P05187
Molecular Weight:57,954 Da
NCBI Full Name:alkaline phosphatase, placental type preproprotein
NCBI Synonym Full Names:alkaline phosphatase, placental
NCBI Official Symbol:ALPP  
NCBI Official Synonym Symbols:ALP; PALP; PLAP; PLAP-1  
NCBI Protein Information:alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme
UniProt Protein Name:Alkaline phosphatase, placental type
UniProt Synonym Protein Names:Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
Protein Family:Phosphatase
UniProt Gene Name:ALPP  
UniProt Entry Name:PPB1_HUMAN
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