Human ALDH3A1 Recombinant Protein (RPPB1388)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB1388
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ALDH3A1
Synonyms:
Aldehyde dehydrogenase 3 family member A1
Synonyms:
aldehyde dehydrogenase
Synonyms:
dimeric NADP-preferring
Synonyms:
ALDH-3
Source:
Escherichia Coli
Uniprot:
P30838
€0.00
Frequently bought together:

Description

Product Name:Human ALDH3A1 Recombinant Protein
Product Code:RPPB1388
Size:10µg
Species:Human
Target:ALDH3A1
Synonyms:Aldehyde dehydrogenase 3 family member A1, aldehyde dehydrogenase, dimeric NADP-preferring, ALDH-3, aldehyde dehydrogenase isozyme, ALDHIII, MGC104062, aldehyde dehydrogenase type III, Aldehyde dehydrogenase, stomach aldehyde dehydrogenase, EC 1.2.1.53, aldehyde dehydrogenase 3A, Aldehyde dehydrogenase.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:ALDH3A1 solution containing 20mM Tris-HCl pH-8, 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNAVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVLPIVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH
Biological Activity:Specific activity was found to be < 1 units/ml. Activity was obtained by measuring the increase of NADP in absorbance at 340 nm resulting from the reduction of NAD. 1 unit will oxidize 1umole of acetaldehyde to acetic acid per minute at pH 8 at 25°C in the presence of beta-NAD, potassium and thiols.

ALDH3A1 is involved in the detoxification of alcohol-derived acetaldehyde. ALDH3A1 participates in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 oxidizes aromatic aldehyde substrates and toxic aldehydes. ALDH3A1 forms a cytoplasmic homodimer that oxidizes aromatic and medium-chain saturated and unsaturated aldehyde substrates. ALDH3A1 promotes resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.

ALDH3A1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 473 amino acids (1-453 a.a.) and having a molecular mass of 52.5 kDa. ALDH3A1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:ALDH3A1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Belongs to the aldehyde dehydrogenase family.
UniProt Protein Details:

Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - phenylalanine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.5; Amino Acid Metabolism - histidine; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tyrosine; Oxidoreductase

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; extracellular space; intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function:3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; benzaldehyde dehydrogenase (NAD+) activity; protein binding

Biological Process: aldehyde metabolic process; xenobiotic metabolic process

NCBI Summary:Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
UniProt Code:P30838
NCBI GenInfo Identifier:311033473
NCBI Gene ID:218
NCBI Accession:P30838.3
UniProt Secondary Accession:P30838,Q9BT37, A8K828,
UniProt Related Accession:P30838
Molecular Weight:50,395 Da
NCBI Full Name:Aldehyde dehydrogenase, dimeric NADP-preferring
NCBI Synonym Full Names:aldehyde dehydrogenase 3 family member A1
NCBI Official Symbol:ALDH3A1  
NCBI Official Synonym Symbols:ALDH3; ALDHIII  
NCBI Protein Information:aldehyde dehydrogenase, dimeric NADP-preferring
UniProt Protein Name:Aldehyde dehydrogenase, dimeric NADP-preferring
UniProt Synonym Protein Names:ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1
Protein Family:Aldehyde dehydrogenase
UniProt Gene Name:ALDH3A1  
UniProt Entry Name:AL3A1_HUMAN
View AllClose

Related Products