Human AKR7A3 Recombinant Protein (RPPB5800)
- SKU:
- RPPB5800
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- AKR7A3
- Synonyms:
- AFAR2
- Aflatoxin B1 aldehyde reductase member 3
- AFB1 aldehyde reductase 2
- AFB1-AR 2
- Source:
- Escherichia Coli
- Uniprot:
- O95154
Description
| Product Name: | Human AKR7A3 Recombinant Protein |
| Product Code: | RPPB5800 |
| Size: | 5µg |
| Species: | Human |
| Target: | AKR7A3 |
| Synonyms: | AFAR2, Aflatoxin B1 aldehyde reductase member 3, AFB1 aldehyde reductase 2, AFB1-AR 2, AKR7A3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The AKR7A3 solution (1mg/ml) contains 10% Glycerol and 20mM Tris-HCl buffer (pH 8.5). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSRQLSRARP ATVLGAMEMG RRMDAPTSAA VTRAFLERGH TEIDTAFVYS EGQSETILGG LGLRLGGSDC RVKIDTKAIP LFGNSLKPDS LRFQLETSLK RLQCPRVDLF YLHMPDHSTP VEETLRACHQ LHQEGKFVEL GLSNYAAWEV AEICTLCKSN GWILPTVYQG MYNAITRQVE TELFPCLRHF GLRFYAFNPL AGGLLTGKYK YEDKDGKQPV GRFFGNTWAE MYRNRYWKEH HFEGIALVEK ALQAAYGASA PSMTSATLRW MYHHSQLQGA HGDAVILGMS SLEQLEQNLA AAEEGPLEPA VVDAFNQAWH LVAHECPNYF R |
| Biological Activity: | Specific activity is > 800pmol/min/ug. It is defined by the amount of enzyme that catalyzes the reduction 1.0pmole of 1,2-Naphthoquinone presence of NADPH per minute at pH 7.0 at 25?C. |
Aldo-Keto Reductase Family 7 Member A3 or AKR7A3, is an enzyme, it is part of the detoxification of aldehydes and ketones process. AKR7A3 diminishes the dialdehyde protein-binding form of aflatoxin B1 to the non-binding AFB1 dialcohol. The enzyme takes partin protection of liver from toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
AKR7A3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 331 amino acids (1-331) and having a molecular mass of 37.7 kDa.AKR7A3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AKR7A3: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.-.-.- Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: cytosol Molecular Function:aldo-keto reductase activity; electron carrier activity; protein binding Biological Process: aldehyde metabolic process; xenobiotic metabolic process |
| NCBI Summary: | Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004] |
| UniProt Code: | O95154 |
| NCBI GenInfo Identifier: | 13123960 |
| NCBI Gene ID: | 22977 |
| NCBI Accession: | O95154.2 |
| UniProt Secondary Accession: | O95154,Q86SR4, Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3, |
| UniProt Related Accession: | O95154 |
| Molecular Weight: | 37,206 Da |
| NCBI Full Name: | Aflatoxin B1 aldehyde reductase member 3 |
| NCBI Synonym Full Names: | aldo-keto reductase family 7 member A3 |
| NCBI Official Symbol: | AKR7A3 |
| NCBI Official Synonym Symbols: | AFAR2 |
| NCBI Protein Information: | aflatoxin B1 aldehyde reductase member 3 |
| UniProt Protein Name: | Aflatoxin B1 aldehyde reductase member 3 |
| UniProt Synonym Protein Names: | AFB1 aldehyde reductase 2; AFB1-AR 2 |
| Protein Family: | Aflatoxin B1 aldehyde reductase |
| UniProt Gene Name: | AKR7A3 |
| UniProt Entry Name: | ARK73_HUMAN |
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