Human AGA Recombinant Protein (RPPB1365)

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SKU:
RPPB1365
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
AGA
Synonyms:
Aspartylglucosaminidase
Synonyms:
AGU
Synonyms:
ASRG
Synonyms:
GA
Source:
Escherichia Coli
Uniprot:
P20933
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Description

Product Name:Human AGA Recombinant Protein
Product Code:RPPB1365
Size:20µg
Species:Human
Target:AGA
Synonyms:Aspartylglucosaminidase, AGU, ASRG, GA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:AGA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSSPLPLV VNTWPFKNAT EAAWRALASG GSALDAVESG CAMCEREQCD GSVGFGGSPD ELGETTLDAM IMDGTTMDVG AVGDLRRIKN AIGVARKVLE HTTHTLLVGE SATTFAQSMG FINEDLSTTA SQALHSDWLA RNCQPNYWRN VIPDPSKYCG PYKPPGILKQ DIPIHKETED DRGHDTIGMV VIHKTGHIAA GTSTNGIKFK IHGRVGDSPI PGAGAYADDT AGAAAATGNG DILMRFLPSY QAVEYMRRGE DPTIACQKVI SRIQKHFPEF FGAVICANVT GSYGAACNKL STFTQFSFMV YNSEKNQPTE EKVDCI

Aspartylglucosaminidase, also known as AGA, takes part in the catabolism of Nlinked oligosaccharides of glycoproteins. AGA is a protein coding gene which cleaves asparagine from N-acetylglucosamines in the lysosomal breakdown of glycoproteins.

AGA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 346 amino acids (24-346 a.a.) and having a molecular mass of 37kDa.AGA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:AGA: a catabolic enzyme, aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.
UniProt Protein Details:

Protein type:Glycan Metabolism - other glycan degradation; EC 3.5.1.26; Hydrolase

Chromosomal Location of Human Ortholog: 4q34.3

Cellular Component: endoplasmic reticulum; lysosome

Molecular Function:peptidase activity; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity; protein self-association

Biological Process: protein deglycosylation; protein maturation; proteolysis

Disease: Aspartylglucosaminuria

NCBI Summary:Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010]
UniProt Code:P20933
NCBI GenInfo Identifier:288558804
NCBI Gene ID:175
NCBI Accession:P20933.2
UniProt Secondary Accession:P20933,Q4W5Q2, Q6FHN6, Q9UCK6, Q9UCK7, Q9UCK8, B2R7H2 D3DP47,
UniProt Related Accession:P20933
Molecular Weight:346
NCBI Full Name:N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
NCBI Synonym Full Names:aspartylglucosaminidase
NCBI Official Symbol:AGA  
NCBI Official Synonym Symbols:GA; AGU; ASRG  
NCBI Protein Information:N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; glycosylasparaginase; aspartylglucosylamine deaspartylase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
UniProt Protein Name:N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
UniProt Synonym Protein Names:Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidaseCleaved into the following 2 chains:Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain
Protein Family:Agaricus bisporus lectin
UniProt Gene Name:AGA  
UniProt Entry Name:ASPG_HUMAN
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