Human ADPRHL2 Recombinant Protein (RPPB1360)

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SKU:
RPPB1360
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
ADPRHL2
Synonyms:
Poly(ADP-ribose) glycohydrolase ARH3
Synonyms:
ADP-ribosylhydrolase 3
Synonyms:
[Protein ADP-ribosylarginine] hydrolase-like protein 2
Synonyms:
ADPRHL2
Source:
Escherichia Coli
Uniprot:
Q9NX46
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Description

Product Name:Human ADPRHL2 Recombinant Protein
Product Code:RPPB1360
Size:20µg
Species:Human
Target:ADPRHL2
Synonyms:Poly(ADP-ribose) glycohydrolase ARH3, ADP-ribosylhydrolase 3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, ADPRHL2, ARH3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ADPRHL2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAAAAM AAAAGGGAGA ARSLSRFRGC LAGALLGDCV GSFYEAHDTV DLTSVLRHVQ SLEPDPGTPG SERTEALYYT DDTAMARALV QSLLAKEAFD EVDMAHRFAQ EYKKDPDRGY GAGVVTVFKK LLNPKCRDVF EPARAQFNGK GSYGNGGAMR VAGISLAYSS VQDVQKFARL SAQLTHASSL GYNGAILQAL AVHLALQGES SSEHFLKQLL GHMEDLEGDA QSVLDARELG MEERPYSSRL KKIGELLDQA SVTREEVVSE LGNGIAAFES VPTAIYCFLR CMEPDPEIPS AFNSLQRTLI YSISLGGDTD TIATMAGAIA GAYYGMDQVP ESWQQSCEGY EETDILAQSL HRVFQKS

ADP-ribosylhydrolase like 2 (ADPRHL2) belongs to the ADP-ribosylglycohydrolase family. ADPRHL2 catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. ADPRHL2, which is ubiquitously expressed, uses magnesium as a cofactor to catalyze the hydrolysis of poly (ADP-ribose) that is synthesized after DNA damage. Furthermore, ADPRHL2 has an essential role in the maintenance of normal neuronal cell function. The ADPRHL2 enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.

ADPRHL2 Human Recombinant produced in E. coli is a single polypeptide chain containing 387 amino acids (1-363) and having a molecular mass of 41.5kDa.ADPRHL2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ADPRHL2: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Belongs to the ADP-ribosylglycohydrolase family.Protein type: Hydrolase; EC 3.2.1.143Chromosomal Location of Human Ortholog: 1p34.3Cellular Component: nucleoplasm
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
UniProt Code:Q9NX46
NCBI GenInfo Identifier:74753038
NCBI Gene ID:54936
NCBI Accession:Q9NX46.1
UniProt Secondary Accession:Q9NX46,Q53G94, Q6IAB8, Q9BY47
UniProt Related Accession:Q9NX46
Molecular Weight:38,947 Da
NCBI Full Name:Poly(ADP-ribose) glycohydrolase ARH3
NCBI Synonym Full Names:ADP-ribosylhydrolase like 2
NCBI Official Symbol:ADPRHL2  
NCBI Official Synonym Symbols:ARH3  
NCBI Protein Information:poly(ADP-ribose) glycohydrolase ARH3
UniProt Protein Name:Poly(ADP-ribose) glycohydrolase ARH3
UniProt Synonym Protein Names:ADP-ribosylhydrolase 3; [Protein ADP-ribosylarginine] hydrolase-like protein 2
Protein Family:Poly(ADP-ribose) glycohydrolase
UniProt Gene Name:ADPRHL2  
UniProt Entry Name:ARHL2_HUMAN
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