Human ACOT7 Recombinant Protein (RPPB1335)

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SKU:
RPPB1335
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
ACOT7
Synonyms:
Cytosolic acyl coenzyme A thioester hydrolase
Synonyms:
Acyl-CoA thioesterase 7
Synonyms:
Brain acyl-CoA hydrolase
Synonyms:
BACH
Source:
Escherichia Coli
Uniprot:
O00154
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Description

Product Name:Human ACOT7 Recombinant Protein
Product Code:RPPB1335
Size:20µg
Species:Human
Target:ACOT7
Synonyms:Cytosolic acyl coenzyme A thioester hydrolase, Acyl-CoA thioesterase 7, Brain acyl-CoA hydrolase, BACH, CTE-IIa, CTE-II, Long chain acyl-CoA thioester hydrolase, ACOT7, ACT, ACH1, LACH, LACH1, hBACH, RP1-120G22.10.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ACOT7 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.15M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MARPGLIHSA PGLPDTCALL QPPAASAAAA PSMSGPDVET PSAIQICRIM RPDDANVAGN VHGGTILKMI EEAGAIISTR HCNSQNGERC VAALARVERT DFLSPMCIGE VAHVSAEITY TSKHSVEVQV NVMSENILTG AKKLTNKATL WYVPLSLKNV DKVLEVPPVV YSRQEQEEEG RKRYEAQKLE RMETKWRNGD IVQPVLNPEP NTVSYSQSSL IHLVGPSDCT LHGFVHGGVT MKLMDEVAGI VAARHCKTNI VTASVDAINF HDKIRKGCVI TISGRMTFTS NKSMEIEVLV DADPVVDSSQ KRYRAASAFF TYVSLSQEGR SLPVPQLVPE TEDEKKRFEE GKGRYLQMKA KRQGHAEPQP

Acyl-CoA Thioesterase 7 (ACOT7) belongs to the acyl coenzyme family. ACOT7 hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of the ACOT7 protein may be linked to mesial temporal lobe epilepsy.

ACOT7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 390 amino acids (1-370) and having a molecular mass of 42.6kDa.ACOT7 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ACOT7: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. 6 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.2.2; Lipid Metabolism - unsaturated fatty acid biosynthesis; HydrolaseChromosomal Location of Human Ortholog: 1p36Cellular Component: nucleoplasm; neuron projection; mitochondrion; cytoplasm; cytosolMolecular Function: protein binding; protein homodimerization activity; acyl-CoA binding; palmitoyl-CoA hydrolase activityBiological Process: medium-chain fatty acid biosynthetic process; coenzyme A biosynthetic process; fatty acid catabolic process
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:O00154
NCBI GenInfo Identifier:75709208
NCBI Gene ID:11332
NCBI Accession:NP_009205.3
UniProt Secondary Accession:O00154
UniProt Related Accession:O00154
Molecular Weight:41kDa
NCBI Full Name:cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa
NCBI Synonym Full Names:acyl-CoA thioesterase 7
NCBI Official Symbol:ACOT7  
NCBI Official Synonym Symbols:ACT; ACH1; BACH; LACH; LACH1; hBACH; CTE-II  
NCBI Protein Information:cytosolic acyl coenzyme A thioester hydrolase
UniProt Protein Name:Cytosolic acyl coenzyme A thioester hydrolase
UniProt Synonym Protein Names:Acyl-CoA thioesterase 7; Brain acyl-CoA hydrolase; BACH; CTE-IIa; CTE-II; Long chain acyl-CoA thioester hydrolase
Protein Family:Cytosolic acyl coenzyme A thioester hydrolase
UniProt Gene Name:ACOT7  
UniProt Entry Name:BACH_HUMAN
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