Human ABCB5 Recombinant Protein (RPES3083)

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SKU:
RPES3083
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human ABCB5 Recombinant Protein

ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.

Product Name:Human ABCB5 Recombinant Protein (RPES3083)
Product Code:RPES3083
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5,
Accession:Q2M3G0
Sequence:Ile141-Val247
Fusion tag:N-Trx
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human ATP-binding cassette sub-family B member 5 is produced by our E.coli expression system and the target gene encoding Ile141-Val247 is expressed with a Trx tag at the N-terminus.
Purity:> 85 % as determined by reducing SDS-PAGE.
Mol Mass:29.4 kDa
AP Mol Mass:30 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB?150mM NaCl,pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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