Human AAGAB Recombinant Protein (RPPB2691)

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SKU:
RPPB2691
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
AAGAB
Synonyms:
P34
Synonyms:
Alpha- and gamma-adaptin-binding protein p34
Source:
Escherichia Coli
Uniprot:
Q6PD74
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Description

Product Name:Human AAGAB Recombinant Protein
Product Code:RPPB2691
Size:20µg
Species:Human
Target:AAGAB
Synonyms:P34, Alpha- and gamma-adaptin-binding protein p34.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:AAGAB protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAAGVPCALV TSCSSVFSGD QLVQHILGTE DLIVEVTSND AVRFYPWTID NKYYSADINL CVVPNKFLVT AEIAESVQAF VVYFDSTQKS GLDSVSSWLP LAKAWLPEVM ILVCDRVSED GINRQKAQEW CIKHGFELVE LSPEELPEED DDFPESTGVK RIVQALNANV WSNVVMKNDR NQGFSLLNSL TGTNHSIGSA DPCHPEQPHL PAADSTESLS DHRGGASNTT DAQVDSIVDP MLDLDIQELA SLTTGGGDVE NFERLFSKLK EMKDKAATLP HEQRKVHAEK VAKAFWMAIG GDRDEIEGLS SDEEH

Alpha & Gamma-Adaptin Binding Protein (AAGAB), which is also known as P34, takes part in membrane traffic and interacts with AP1G1 and AP2A1.AAGAB is highly expressed in skin and keratinocytes, with the highest levels in adrenal gland, rectum and thymus.

AAGAB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 335 amino acids (1-315 a.a.) and having a molecular mass of 36.7kDa.AAGAB is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:May be involved in endocytic recycling of growth factor receptors such as EGFR.
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Code:Q6PD74
NCBI GenInfo Identifier:153251315
NCBI Gene ID:79719
NCBI Accession:NP_078942
UniProt Secondary Accession:Q6PD74,Q6FI86, Q7Z5X9, Q9H0P1, Q9HAK0, B4DG44
UniProt Related Accession:Q6PD74
Molecular Weight:36.7kDa (335aa), confirmed by MALDI-TOF
NCBI Full Name:alpha- and gamma-adaptin-binding protein p34 isoform 1
NCBI Synonym Full Names:alpha and gamma adaptin binding protein
NCBI Official Symbol:AAGAB  
NCBI Official Synonym Symbols:p34; KPPP1; PPKP1; PPKP1A  
NCBI Protein Information:alpha- and gamma-adaptin-binding protein p34
UniProt Protein Name:Alpha- and gamma-adaptin-binding protein p34
UniProt Synonym Protein Names:
Protein Family:Alpha- and gamma-adaptin-binding protein
UniProt Gene Name:AAGAB  
UniProt Entry Name:
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