HSD17B7 Antibody (PACO53286)
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주문- SKU:
- PACO53286
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HSD17B7 Antibody (PACO53286) |
Antibody SKU: | PACO53286 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 3-keto-steroid reductase protein (128-198AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO53286 at dilution of 1:100. |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO53286 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Responsible for the reduction of the keto group on the C-3 of sterols. |
Synonyms: | 3-keto-steroid reductase (EC 1.1.1.270) (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1), HSD17B7, SDR37C1 |
UniProt Protein Function: | HSD17B7: Responsible for the reduction of the keto group on the C-3 of sterols. Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; EC 1.1.1.62; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; EC 1.1.1.270 Chromosomal Location of Human Ortholog: 1q23 Cellular Component: endoplasmic reticulum membrane Molecular Function:3-keto sterol reductase activity Biological Process: cholesterol biosynthetic process |
NCBI Summary: | HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010] |
UniProt Code: | P56937 |
NCBI GenInfo Identifier: | 8134404 |
NCBI Gene ID: | 51478 |
NCBI Accession: | P56937.1 |
UniProt Secondary Accession: | P56937,Q5T246, Q7Z4V9, Q8WWS2, Q9UF00, |
UniProt Related Accession: | P56937 |
Molecular Weight: | 34,476 Da |
NCBI Full Name: | 3-keto-steroid reductase |
NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 7 |
NCBI Official Symbol: | HSD17B7 |
NCBI Official Synonym Symbols: | PRAP; SDR37C1 |
NCBI Protein Information: | 3-keto-steroid reductase |
UniProt Protein Name: | 3-keto-steroid reductase |
UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.62); Short chain dehydrogenase/reductase family 37C member 1 |
UniProt Gene Name: | HSD17B7 |
UniProt Entry Name: | DHB7_HUMAN |