HOMER1 Antibody (PACO31592)
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주문- SKU:
- PACO31592
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HOMER1 Antibody (PACO31592) |
Antibody SKU: | PACO31592 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Homer protein homolog 1 protein (1-354AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded LO2 cells using PACO31592 at dilution of 1:50. |
Background: | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). |
Synonyms: | Homer protein homolog 1 (Homer-1), HOMER1, SYN47 |
UniProt Protein Function: | HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 5q14.2Cellular Component: postsynaptic membrane; costamere; cell soma; axon; apical part of cell; excitatory synapse; dendritic shaft; Z disc; cell junctionMolecular Function: identical protein binding; metabotropic glutatmate receptor binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; protein complex scaffoldBiological Process: skeletal muscle contraction; circadian rhythm; response to nicotine; synaptic transmission; positive regulation of signal transduction; chemical homeostasis within a tissue; behavioral response to cocaine; metabotropic glutamate receptor, phospholipase C activating pathway; skeletal muscle fiber development; response to calcium ion; positive regulation of calcium ion transport |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q86YM7 |
NCBI GenInfo Identifier: | 38604765 |
NCBI Gene ID: | 9456 |
NCBI Accession: | Q86YM7.2 |
UniProt Secondary Accession: | Q86YM7 |
UniProt Related Accession: | Q86YM7 |
Molecular Weight: | |
NCBI Full Name: | Homer protein homolog 1 |
NCBI Synonym Full Names: | homer scaffold protein 1 |
NCBI Official Symbol: | HOMER1 |
NCBI Official Synonym Symbols: | HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C |
NCBI Protein Information: | homer protein homolog 1 |
UniProt Protein Name: | Homer protein homolog 1 |
UniProt Synonym Protein Names: | |
Protein Family: | |
UniProt Gene Name: | HOMER1 |
UniProt Entry Name: | HOME1_HUMAN |
Antibodies |
HOMER1 Antibody (PACO09770) |
Secondary Antibody |
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