HOMER1 Antibody (PACO16474)
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주문- SKU:
- PACO16474
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HOMER1 Antibody (PACO16474) |
Antibody SKU: | PACO16474 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human HOMER1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO16474(HOMER1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16474(HOMER1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. |
Synonyms: | homer homolog 1 |
UniProt Protein Function: | HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 5q14.2Cellular Component: postsynaptic membrane; costamere; cell soma; axon; apical part of cell; excitatory synapse; dendritic shaft; Z disc; cell junctionMolecular Function: identical protein binding; metabotropic glutatmate receptor binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; protein complex scaffoldBiological Process: skeletal muscle contraction; circadian rhythm; response to nicotine; synaptic transmission; positive regulation of signal transduction; chemical homeostasis within a tissue; behavioral response to cocaine; metabotropic glutamate receptor, phospholipase C activating pathway; skeletal muscle fiber development; response to calcium ion; positive regulation of calcium ion transport |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q86YM7 |
NCBI GenInfo Identifier: | 38604765 |
NCBI Gene ID: | 9456 |
NCBI Accession: | Q86YM7.2 |
UniProt Secondary Accession: | Q86YM7 |
UniProt Related Accession: | Q86YM7 |
Molecular Weight: | |
NCBI Full Name: | Homer protein homolog 1 |
NCBI Synonym Full Names: | homer scaffold protein 1 |
NCBI Official Symbol: | HOMER1 |
NCBI Official Synonym Symbols: | HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C |
NCBI Protein Information: | homer protein homolog 1 |
UniProt Protein Name: | Homer protein homolog 1 |
UniProt Synonym Protein Names: | |
Protein Family: | |
UniProt Gene Name: | HOMER1 |
UniProt Entry Name: | HOME1_HUMAN |
Antibodies |
HOMER1 Antibody (PACO09770) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |