HGS Antibody (PACO23720)
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주문- SKU:
- PACO23720
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | HGS Antibody (PACO23720) |
Antibody SKU: | PACO23720 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from internal of human HGS. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from 293 cells and JK cells, using HGS antibody. |
![]() | Immunofluorescence analysis of HUVEC cells, using HGS antibody. |
![]() | Immunohistochemistry analysis of paraffin-embedded human testis tissue using HGS antibody. |
Background: | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
Synonyms: | HGS; Hepatocyte growth factor-regulated tyrosine kinase substrate; IMOS-1; |
UniProt Protein Function: | Hrs: a zinc finger protein which is rapidly tyrosine phosphorylated in cells stimulated with various growth factors. Hrs mRNA is expressed in all the human adult and fetal tissues tested. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q25 Cellular Component: cytoplasm; cytosol; early endosome; early endosome membrane; endosome; intracellular membrane-bound organelle Molecular Function:metal ion binding; protein binding; protein domain specific binding Biological Process: autophagy; endosome transport; epidermal growth factor receptor signaling pathway; membrane invagination; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; post-Golgi vesicle-mediated transport; protein targeting to lysosome; regulation of MAP kinase activity; regulation of protein catabolic process; signal transduction |
NCBI Summary: | The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] |
UniProt Code: | O14964 |
NCBI GenInfo Identifier: | 71152119 |
NCBI Gene ID: | 9146 |
NCBI Accession: | O14964.1 |
UniProt Secondary Accession: | O14964,Q9NR36, |
UniProt Related Accession: | O14964 |
Molecular Weight: | 76,376 Da |
NCBI Full Name: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
NCBI Synonym Full Names: | hepatocyte growth factor-regulated tyrosine kinase substrate |
NCBI Official Symbol: | HGS |
NCBI Official Synonym Symbols: | HRS |
NCBI Protein Information: | hepatocyte growth factor-regulated tyrosine kinase substrate |
UniProt Protein Name: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
UniProt Synonym Protein Names: | Hrs |
Protein Family: | Hepatocyte growth factor-regulated tyrosine kinase substrate |
UniProt Gene Name: | HGS |
UniProt Entry Name: | HGS_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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