HAS3 Antibody (PACO42894)
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주문- SKU:
- PACO42894
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HAS3 Antibody (PACO42894) |
Antibody SKU: | PACO42894 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Hyaluronan synthase 3 protein (339-553AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO42894 at dilution of 1:100. |
![]() | Immunofluorescent analysis of U251 cells using PACO42894 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human cervical cancer using PACO42894 at dilution of 1:100. |
Background: | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. |
Synonyms: | Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid, synthase 3) (HA synthase 3), HAS3 |
UniProt Protein Function: | HAS3: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Belongs to the NodC/HAS family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 2.4.1.212; Transferase; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:hyaluronan synthase activity Biological Process: carbohydrate metabolic process; cell adhesion; extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; positive regulation of transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
UniProt Code: | O00219 |
NCBI GenInfo Identifier: | 206729920 |
NCBI Gene ID: | 3038 |
NCBI Accession: | O00219.3 |
UniProt Secondary Accession: | O00219,Q8WTZ0, Q9NYP0, A8K5T5, |
UniProt Related Accession: | O00219 |
Molecular Weight: | 31,200 Da |
NCBI Full Name: | Hyaluronan synthase 3 |
NCBI Synonym Full Names: | hyaluronan synthase 3 |
NCBI Official Symbol: | HAS3 |
NCBI Protein Information: | hyaluronan synthase 3 |
UniProt Protein Name: | Hyaluronan synthase 3 |
UniProt Synonym Protein Names: | Hyaluronate synthase 3; Hyaluronic acid synthase 3; HA synthase 3 |
Protein Family: | Hyaluronan synthase |
UniProt Gene Name: | HAS3 |
UniProt Entry Name: | HYAS3_HUMAN |