HAS1 Antibody (PACO19748)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO19748
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HAS1 Antibody (PACO19748) |
Antibody SKU: | PACO19748 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human HAS1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19748(HAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, Human prostate tissue, Primary antibody: PACO19748(HAS1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19748(HAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Hyaluronan or hyaluronic acid, (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid, and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. |
Synonyms: | hyaluronan synthase 1 |
UniProt Protein Function: | HAS1: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate. Belongs to the NodC/HAS family. |
UniProt Protein Details: | Protein type:Cell adhesion; EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase Chromosomal Location of Human Ortholog: 19q13.41 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:hyaluronan synthase activity Biological Process: cell adhesion; extracellular polysaccharide biosynthetic process; glycosaminoglycan biosynthetic process; hyaluronan biosynthetic process |
NCBI Summary: | Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q92839 |
NCBI GenInfo Identifier: | 209572627 |
NCBI Gene ID: | 3036 |
NCBI Accession: | Q92839.2 |
UniProt Secondary Accession: | Q92839,Q14470, Q9NS49, |
UniProt Related Accession: | Q92839 |
Molecular Weight: | 65kDa |
NCBI Full Name: | Hyaluronan synthase 1 |
NCBI Synonym Full Names: | hyaluronan synthase 1 |
NCBI Official Symbol: | HAS1 |
NCBI Official Synonym Symbols: | HAS |
NCBI Protein Information: | hyaluronan synthase 1 |
UniProt Protein Name: | Hyaluronan synthase 1 |
UniProt Synonym Protein Names: | Hyaluronate synthase 1; Hyaluronic acid synthase 1; HA synthase 1; HuHAS1 |
Protein Family: | Hyaluronan synthase |
UniProt Gene Name: | HAS1 |
Antibodies | ELISA Kits |
Anti-HAS1 Antibody (CAB10453) | Human HAS1 / Hyaluronan synthase 1 ELISA Kit |
Human Hyaluronan synthase 1 (HAS1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |