HACE1 Antibody (PACO19747)
- SKU:
- PACO19747
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HACE1 Antibody (PACO19747) |
Antibody SKU: | PACO19747 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:100-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human HACE1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19747(HACE1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19747(HACE1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | HACE1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1), also known as KIAA1320, is a 909 amino acid, protein that localizes to both the cytoplasm and the endoplasmic reticulum and contains one HECT domain and six ANK repeats. Expressed in kidney, heart and brain, HACE1 functions as an E3 ubiquitin-protein ligase that interacts with the proteasome and is thought to play a role in protein degradation. HACE1 is downregulated in Wilms tumor, suggesting a possible role in tumor suppression. |
Synonyms: | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 |
UniProt Protein Function: | HAS1: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate. Belongs to the NodC/HAS family. |
UniProt Protein Details: | Protein type:Cell adhesion; EC 2.4.1.212; Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass; Transferase Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane Molecular Function:hyaluronan synthase activity Biological Process: carbohydrate metabolic process; cell adhesion; extracellular polysaccharide biosynthetic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; hyaluronan biosynthetic process; hyaluronan metabolic process |
NCBI Summary: | This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016] |
UniProt Code: | Q8IYU2 |
NCBI GenInfo Identifier: | 116875852 |
NCBI Gene ID: | 57531 |
NCBI Accession: | NP_065822 |
UniProt Related Accession: | Q8IYU2 |
Molecular Weight: | 76kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase HACE1 isoform a |
NCBI Synonym Full Names: | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 |
NCBI Official Symbol: | HACE1 |
NCBI Official Synonym Symbols: | SPPRS |
NCBI Protein Information: | E3 ubiquitin-protein ligase HACE1 |
UniProt Protein Name: | Hyaluronan synthase 1 |
UniProt Synonym Protein Names: | Hyaluronate synthase 1; Hyaluronic acid synthase 1; HA synthase 1; HuHAS1 |
Protein Family: | Hyaluronan synthase |
UniProt Gene Name: | HAS1 |
UniProt Entry Name: | HYAS1_HUMAN |
Antibodies | ELISA Kits |
Anti-HACE1 Antibody (CAB9593) | Human HACE1 ELISA Kit |
Human E3 ubiquitin-protein ligase HACE1 (HACE1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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