UniProt Protein Function: | H1F0: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. Belongs to the histone H1/H5 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; Golgi apparatus; nuclear chromatin; nucleosome; nucleus; actin cytoskeleton Molecular Function:protein binding; chromatin DNA binding Biological Process: nucleosome assembly; apoptosis; DNA fragmentation during apoptosis; cell structure disassembly during apoptosis |
NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family. [provided by RefSeq, Jul 2008] |
UniProt Code: | P07305 |
NCBI GenInfo Identifier: | 121897 |
NCBI Gene ID: | 3005 |
NCBI Accession: | P07305.3 |
UniProt Secondary Accession: | P07305,Q6FG88, Q8N6R3, B2R6I0, B4DRD6, |
UniProt Related Accession: | P07305 |
Molecular Weight: | 194 |
NCBI Full Name: | Histone H1.0 |
NCBI Synonym Full Names: | H1 histone family, member 0 |
NCBI Official Symbol: | H1F0 |
NCBI Official Synonym Symbols: | H10; H1FV |
NCBI Protein Information: | histone H1.0; histone H1'; histone H1(0); H1.0, H1(0), H1-0 |
UniProt Protein Name: | Histone H1.0 |
UniProt Synonym Protein Names: | Histone H1'; Histone H1(0)Histone H1.0, N-terminally processed |
Protein Family: | Histone |
UniProt Gene Name: | H1F0 |
UniProt Entry Name: | H10_HUMAN |