GSR Antibody (PACO14490)
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주문- SKU:
- PACO14490
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GSR Antibody (PACO14490) |
Antibody SKU: | PACO14490 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human GSR |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, Hela cells, A549 cells, Primary antibody: PACO14490(GSR Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14490(GSR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. |
Synonyms: | Glutathione reductase |
UniProt Protein Function: | GSR: a class-I pyridine nucleotide-disulfide oxidoreductase. Maintains high levels of reduced glutathione in the cytosol. Alternative initiation results in a mitochondrial and a cytoplasmic isoform. |
UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione; Oxidoreductase; EC 1.8.1.7 Chromosomal Location of Human Ortholog: 8p21.1 Cellular Component: cytosol; mitochondrial matrix Molecular Function:electron carrier activity; glutathione-disulfide reductase activity Biological Process: nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species |
NCBI Summary: | This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010] |
UniProt Code: | P00390 |
NCBI GenInfo Identifier: | 14916998 |
NCBI Gene ID: | 2936 |
NCBI Accession: | P00390.2 |
UniProt Secondary Accession: | P00390,Q7Z5C9, Q9NP63, C8KIL8, C8KIL9, C8KIM0, D3DSV3 |
UniProt Related Accession: | P00390 |
Molecular Weight: | 47,267 Da |
NCBI Full Name: | Glutathione reductase, mitochondrial |
NCBI Synonym Full Names: | glutathione-disulfide reductase |
NCBI Official Symbol: | GSR |
NCBI Official Synonym Symbols: | HEL-75; HEL-S-122m |
NCBI Protein Information: | glutathione reductase, mitochondrial |
UniProt Protein Name: | Glutathione reductase, mitochondrial |
Protein Family: | Glutathione reductase |
UniProt Gene Name: | GSR |
UniProt Entry Name: | GSHR_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |