GRPR Antibody (PACO56812)
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주문- SKU:
- PACO56812
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GRPR Antibody (PACO56812) |
Antibody SKU: | PACO56812 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Gastrin-releasing peptide receptor protein (326-384AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of PC-3 cells with PACO56812 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | IHC image of PACO56812 diluted at 1:300 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO56812 diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity). |
Synonyms: | Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor), GRPR |
UniProt Protein Function: | GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:bombesin receptor activity; peptide receptor activity, G-protein coupled Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation |
NCBI Summary: | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30550 |
NCBI GenInfo Identifier: | 232185 |
NCBI Gene ID: | 2925 |
NCBI Accession: | P30550.1 |
UniProt Secondary Accession: | P30550,B2R910, |
UniProt Related Accession: | P30550,AAB27329 |
Molecular Weight: | 384 |
NCBI Full Name: | Gastrin-releasing peptide receptor |
NCBI Synonym Full Names: | gastrin-releasing peptide receptor |
NCBI Official Symbol: | GRPR |
NCBI Official Synonym Symbols: | BB2 |
NCBI Protein Information: | gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor |
UniProt Protein Name: | Gastrin-releasing peptide receptor |
UniProt Synonym Protein Names: | GRP-preferring bombesin receptor |
Protein Family: | Gastrin-releasing peptide receptor |
UniProt Gene Name: | GRPR |
UniProt Entry Name: | GRPR_HUMAN |
Antibodies | ELISA Kits |
Anti-GRPR Antibody (CAB2940) | Human GRPR (Gastrin-releasing peptide receptor) ELISA Kit (HUFI05186) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |