UniProt Protein Function: | GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:bombesin receptor activity; peptide receptor activity, G-protein coupled Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation |
NCBI Summary: | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P30550 |
NCBI GenInfo Identifier: | 232185 |
NCBI Gene ID: | 2925 |
NCBI Accession: | P30550.1 |
UniProt Secondary Accession: | P30550,B2R910, |
UniProt Related Accession: | P30550,AAB27329 |
Molecular Weight: | 384 |
NCBI Full Name: | Gastrin-releasing peptide receptor |
NCBI Synonym Full Names: | gastrin-releasing peptide receptor |
NCBI Official Symbol: | GRPR |
NCBI Official Synonym Symbols: | BB2 |
NCBI Protein Information: | gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor |
UniProt Protein Name: | Gastrin-releasing peptide receptor |
UniProt Synonym Protein Names: | GRP-preferring bombesin receptor |
Protein Family: | Gastrin-releasing peptide receptor |
UniProt Gene Name: | GRPR |
UniProt Entry Name: | GRPR_HUMAN |