UniProt Protein Function: | mGluR4: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell development/differentiation; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 3 Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: presynaptic membrane; integral to plasma membrane; plasma membrane; terminal button; presynaptic active zone membrane; intracellular; cytoplasmic vesicle; dendritic shaft Molecular Function:calmodulin binding; G-protein coupled receptor activity; group III metabotropic glutamate receptor activity; glutamate receptor activity; calcium-dependent protein binding Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; positive regulation of MAPKKK cascade; activation of MAPK activity; neurotransmitter secretion; regulation of neuron apoptosis; learning; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway |
NCBI Summary: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q14833 |
NCBI GenInfo Identifier: | 2495077 |
NCBI Gene ID: | 2914 |
NCBI Accession: | Q14833.1 |
UniProt Secondary Accession: | Q14833,Q5SZ84, Q6ZMQ2, B3KVL9, B7Z1T9, B7Z1U6, F5GXM5 |
UniProt Related Accession: | Q14833,AAB34891 |
Molecular Weight: | |
NCBI Full Name: | Metabotropic glutamate receptor 4 |
NCBI Synonym Full Names: | glutamate receptor, metabotropic 4 |
NCBI Official Symbol: | GRM4 |
NCBI Official Synonym Symbols: | mGlu4; GPRC1D; MGLUR4 |
NCBI Protein Information: | metabotropic glutamate receptor 4 |
UniProt Protein Name: | Metabotropic glutamate receptor 4 |
Protein Family: | Metabotropic glutamate receptor |
UniProt Gene Name: | GRM4 |
UniProt Entry Name: | GRM4_HUMAN |