UniProt Protein Function: | GluR7: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: axon; dendrite; dendrite cytoplasm; integral to plasma membrane; perikaryon; plasma membrane; terminal button Molecular Function:adenylate cyclase inhibiting metabotropic glutamate receptor activity; G-protein-coupled receptor binding; glutamate receptor activity; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity Biological Process: glutamate signaling pathway; metabotropic glutamate receptor signaling pathway; negative regulation of synaptic transmission, glutamatergic; regulation of membrane potential |
NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13003 |
NCBI GenInfo Identifier: | 212276502 |
NCBI Gene ID: | 2899 |
NCBI Accession: | Q13003.3 |
UniProt Secondary Accession: | Q13003,Q13004, Q16136, A9Z1Z8, B1AMS6, |
UniProt Related Accession: | Q13003 |
Molecular Weight: | 98,727 Da |
NCBI Full Name: | Glutamate receptor ionotropic, kainate 3 |
NCBI Synonym Full Names: | glutamate ionotropic receptor kainate type subunit 3 |
NCBI Official Symbol: | GRIK3 |
NCBI Official Synonym Symbols: | EAA5; GLR7; GLUR7; GluK3; GluR7a |
NCBI Protein Information: | glutamate receptor ionotropic, kainate 3 |
UniProt Protein Name: | Glutamate receptor ionotropic, kainate 3 |
UniProt Synonym Protein Names: | Excitatory amino acid receptor 5; EAA5; Glutamate receptor 7; GluR-7; GluR7 |
Protein Family: | Glutamate receptor ionotropic |
UniProt Gene Name: | GRIK3 |
UniProt Entry Name: | GRIK3_HUMAN |